MATK: Megakaryocyte-Associated Tyrosine Kinase
A non-receptor tyrosine kinase involved in hematopoiesis and immune signaling
Gene Information Card
| Symbol | MATK |
|---|---|
| Full Name | Megakaryocyte-Associated Tyrosine Kinase |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 4145 ncbi.nlm.nih.gov/gene/4145 |
| Ensembl ID | ENSG00000104872 |
| UniProt ID | P42679 |
| OMIM ID | 600038 |
| HGNC ID | 6906 |
| Aliases | CTK, CHK, HHYLTK, Lsk, MGC1708, MGC126563, MGC126565 |
Description
MATK (megakaryocyte-associated tyrosine kinase) encodes a non-receptor tyrosine kinase belonging to the CSK family. The protein negatively regulates Src family kinases by phosphorylating their C-terminal tyrosine residue, thereby modulating signal transduction pathways involved in hematopoiesis, immune cell activation, and cell proliferation. MATK is predominantly expressed in hematopoietic tissues, particularly megakaryocytes and T cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Leukemia | Dysregulation of Src kinase signaling due to altered MATK expression | COSMIC, ClinVar |
| Myelodysplastic syndromes | Reduced MATK expression may contribute to abnormal hematopoiesis | NCBI Gene, PubMed |
| Immune system disorders | Impaired negative regulation of T-cell receptor signaling | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lymph node | 6.7 | Low |
| Thymus | 5.9 | Low |
| Whole blood | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.2 | High expression |
| HL-60 (promyeloblast) | 10.8 | Medium expression |
| Jurkat (T-cell) | 9.5 | Medium expression |
| HEK 293 (embryonic kidney) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.1% | Unknown functional effect |
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Reported in COSMIC |
| c.1024_1025insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the kinase domain, impairing negative regulation of Src kinases.
Gain of Function (GOF)
Not well characterized; rare missense variants may alter substrate specificity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
Pathways
• T-cell receptor signaling pathway (KEGG: hsa04660)
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Regulation of Src family kinases (Reactome: R-HSA-912526)
Protein Summary
The MATK protein (42679 Da) is a cytoplasmic tyrosine kinase containing SH2, SH3, and catalytic domains. It phosphorylates the C-terminal regulatory tyrosine of Src family kinases (e.g., SRC, LCK, FYN), leading to their inactivation. This negative regulation is critical for controlling immune cell activation and hematopoietic differentiation. MATK is also known as CSK-type kinase (CTK) or hematopoietic consensus kinase (CHK).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MATK Knockout HEK293 Cell Line | EDJ-KQ3672 | Human | 4145 | Details Get a Quote |
| MATK Knockout HeLa Cell Line | EDJ-KQ53843 | Human | 4145 | Details Get a Quote |
| MATK Knockout A-549 Cell Line | EDJ-KQ62329 | Human | 4145 | Details Get a Quote |
| MATK Knockout HCT 116 Cell Line | EDJ-KQ70802 | Human | 4145 | Details Get a Quote |
