MAS1: MAS1 Proto-Oncogene, G Protein-Coupled Receptor
A key component of the renin-angiotensin system with roles in cardiovascular and neurological function
Gene Information Card
| Symbol | MAS1 |
|---|---|
| Full Name | MAS1 proto-oncogene, G protein-coupled receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 6q25.3 |
| NCBI Gene ID | 4142 ncbi.nlm.nih.gov/gene/4142 |
| Ensembl ID | ENSG00000130368 |
| UniProt ID | P04201 |
| OMIM ID | 601572 |
| HGNC ID | 6899 |
| Aliases | MAS, MAS1 oncogene, MGRA |
Description
The MAS1 gene encodes a G protein-coupled receptor (GPCR) that functions as a receptor for angiotensin-(1-7), a vasoactive peptide of the renin-angiotensin system. It mediates vasodilation, anti-proliferative, and anti-inflammatory effects, counterbalancing the actions of the angiotensin II type 1 receptor. MAS1 is involved in cardiovascular regulation, neuroprotection, and metabolic homeostasis. It was originally identified as a proto-oncogene from a human epidermoid carcinoma cell line.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cardiovascular disease | MAS1 signaling via angiotensin-(1-7) promotes vasodilation and reduces blood pressure; dysregulation contributes to hypertension and heart failure | ClinVar, OMIM |
| Neurological disorders | MAS1 activation exerts neuroprotective effects; altered expression linked to Alzheimer's disease and stroke | NCBI Gene, OMIM |
| Metabolic syndrome | MAS1 modulates insulin sensitivity and glucose metabolism; deficiency associated with insulin resistance | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Kidney | 15.1 | Medium |
| Liver | 2.4 | Not detected |
| Lung | 6.7 | Low |
| Testis | 20.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.2 | Moderate expression |
| SH-SY5Y | 22.5 | High expression |
| HUVEC | 9.8 | Low expression |
| HepG2 | 3.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
| c.200G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for MAS1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ClinVar or COSMIC for MAS1.
Dominant Negative (DN)
No dominant-negative mutations reported for MAS1.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • angiotensin receptor activity |
| • angiotensin-(1-7) receptor activity | • signal transduction |
| • vasodilation | • negative regulation of cell proliferation |
| • inflammatory response |
Pathways
• Renin-angiotensin system
• GPCR downstream signaling
• Angiotensin-(1-7) signaling pathway
Protein Summary
The MAS1 protein is a 325-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by angiotensin-(1-7) and couples primarily to Gαi/o proteins, leading to inhibition of adenylyl cyclase and activation of downstream kinases such as PI3K/Akt and MAPK. MAS1 is expressed in brain, heart, kidney, and testis, where it mediates vasodilation, anti-fibrotic, and anti-inflammatory effects. It plays a protective role in cardiovascular and neurological diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAS1 Knockout HEK293 Cell Line | EDJ-KQ5180 | Human | 4142 | Details Get a Quote |
| MAS1L Knockout HEK293 Cell Line | EDJ-KQ7575 | Human | 116511 | Details Get a Quote |
| MAS1 Knockout MDCK Cell Line | EDJ-KZ342 | Dog | 4142 | Details Get a Quote |
| MAS1 Knockout HeLa Cell Line | EDJ-KQ53841 | Human | 4142 | Details Get a Quote |
| MAS1L Knockout HeLa Cell Line | EDJ-KQ57992 | Human | 116511 | Details Get a Quote |
| MAS1 Knockout A-549 Cell Line | EDC08223 | Human | 4142 | Details Get a Quote |
| MAS1L Knockout A-549 Cell Line | EDJ-KQ66478 | Human | 116511 | Details Get a Quote |
| MAS1 Knockout HCT 116 Cell Line | EDJ-KQ70801 | Human | 4142 | Details Get a Quote |
| MAS1L Knockout HCT 116 Cell Line | EDJ-KQ74901 | Human | 116511 | Details Get a Quote |
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