MAPK8IP2 Gene
Mitogen-Activated Protein Kinase 8 Interacting Protein 2
Gene Information Card
| Symbol | MAPK8IP2 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 8 Interacting Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.33 |
| NCBI Gene ID | 23542 ncbi.nlm.nih.gov/gene/23542 |
| Ensembl ID | ENSG00000100234 |
| UniProt ID | Q13387 |
| OMIM ID | 607755 |
| HGNC ID | 6883 |
| Aliases | JIP2, IB2, PRKM8IP2, JNK-interacting protein 2 |
Description
MAPK8IP2 encodes a scaffold protein that specifically interacts with mitogen-activated protein kinase 8 (MAPK8/JNK1) and other JNK signaling components. It modulates JNK activation by assembling specific kinase complexes and influences neuronal development, insulin signaling, and cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | Impaired JNK-mediated insulin signaling; MAPK8IP2 variants may alter scaffold function affecting glucose homeostasis | PMID: 12524439 |
| Neurodegenerative Disorders (Alzheimer's, Parkinson's) | Dysregulation of JNK pathway; MAPK8IP2 modulates tau phosphorylation and neuronal apoptosis | PMID: 15689499 |
| Cancer (various) | Altered JNK scaffold expression influences cell proliferation and apoptosis; potential tumor suppressor role | COSMIC: MAPK8IP2 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 4.1 | Low |
| Kidney | 6.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 14.0 | Neuronal model |
| HeLa (cervical) | 5.2 | Low expression |
| HEK293 (embryonic kidney) | 7.8 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Altered JNK binding affinity |
| c.457C>T (p.Arg153Trp) | Missense | <0.01% | Potential loss of scaffold function |
| c.789_790insA (p.Glu264fs) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein likely impair JNK scaffold activity.
Gain of Function (GOF)
Not reported; no activating mutations documented.
Dominant Negative (DN)
Missense variants that disrupt JNK binding without complete loss may act dominant-negatively.
View complete mutation data：
Gene Ontology (GO)
Pathways
• JNK signaling pathway (Reactome: R-HSA-450294)
• MAPK signaling pathway (KEGG: hsa04010)
• Neurotrophin signaling pathway (KEGG: hsa04722)
Protein Summary
MAPK8IP2 (JIP2) is a 824-amino acid scaffold protein that organizes JNK signaling modules. It contains a JNK-binding domain (JBD) and a SH3 domain, facilitating interactions with MAPK8, MAP2K7, and MAP3K1. JIP2 is predominantly expressed in brain and testis, where it regulates neuronal differentiation, apoptosis, and stress responses. Alternative splicing produces multiple isoforms.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK8IP2 Knockout HEK293 Cell Line | EDJ-KQ703 | Human | 23542 | Details Get a Quote |
| MAPK8IP2 Knockout A-549 Cell Line | EDJ-KQ19290 | Human | 23542 | Details Get a Quote |
| MAPK8IP2 Knockout HCT 116 Cell Line | EDJ-KQ19291 | Human | 23542 | Details Get a Quote |
| MAPK8IP2 Knockout HeLa Cell Line | EDJ-KQ55763 | Human | 23542 | Details Get a Quote |
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