MAPK7: Mitogen-Activated Protein Kinase 7 (ERK5)
A key signaling kinase in cell proliferation, differentiation, and survival, implicated in cancer and developmental disorders.
Gene Information Card
| Symbol | MAPK7 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p11.2 |
| NCBI Gene ID | 5598 ncbi.nlm.nih.gov/gene/5598 |
| Ensembl ID | ENSG00000100030 |
| UniProt ID | Q13164 |
| OMIM ID | 602521 |
| HGNC ID | 6878 |
| Aliases | ERK5, BMK1, PRKM7 |
Description
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | MAPK7 overexpression or constitutive activation promotes tumor growth and metastasis via transcriptional regulation of c-Jun, MEF2, and other targets. | COSMIC; PMID: 25605248 |
| Cardiovascular defects | MAPK7 knockout mice show embryonic lethality due to impaired cardiac development and vascular integrity. | OMIM #602521; PMID: 10572027 |
| Neurodevelopmental disorders | Rare MAPK7 missense variants have been associated with intellectual disability and autism spectrum disorder. | ClinVar; PMID: 31036916 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal Muscle | 8.3 | Low |
| Brain | 6.7 | Low |
| Lung | 5.9 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical carcinoma; high expression |
| A549 | 10.1 | Lung adenocarcinoma; moderate expression |
| MCF7 | 7.8 | Breast cancer; moderate expression |
| HEK293 | 6.5 | Embryonic kidney; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1132G>A (p.Glu378Lys) | Missense | <0.1% | Gain-of-function; increased kinase activity in cancer cell lines |
| c.1465C>T (p.Arg489Trp) | Missense | <0.1% | Loss-of-function; reduced phosphorylation of downstream targets |
| c.1681_1683del (p.Lys561del) | In-frame deletion | <0.1% | Dominant-negative; impairs MEK5 binding |
Mutation functional classification
Loss of Function (LOF)
p.Arg489Trp reduces kinase activity and downstream signaling.
Gain of Function (GOF)
p.Glu378Lys increases autophosphorylation and target activation.
Dominant Negative (DN)
p.Lys561del blocks MEK5-mediated activation.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • MAP kinase activity |
| • ATP binding | • nucleus |
| • cytoplasm | • signal transduction |
| • cell proliferation | • positive regulation of transcription |
| • DNA-templated |
Pathways
• MAPK7 (mitogen-activated protein kinase 7)
• also known as ERK5 or BMK1
• encodes a member of the MAP kinase family. This kinase is activated by upstream kinases (MEK5) in response to growth factors and stress stimuli
• and phosphorylates downstream targets involved in cell proliferation
• differentiation
• survival
• and angiogenesis. MAPK7 is essential for cardiovascular development and has been implicated in various cancers and neurodegenerative diseases.
• MAPK signaling pathway (KEGG: hsa04010)
• ErbB signaling pathway (KEGG: hsa04012)
• Neurotrophin signaling pathway (KEGG: hsa04722)
• MEK5-ERK5 signaling
• MAPK7 (ERK5) is a 816-amino acid serine/threonine kinase with an N-terminal kinase domain and a unique C-terminal tail containing nuclear localization and transactivation domains. It is activated by MEK5 via dual phosphorylation on Thr218 and Tyr220. ERK5 regulates gene expression through phosphorylation of transcription factors such as MEF2
• c-Jun
• and Sap1a
• and is critical for cell cycle progression
• survival
• and angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK7 Knockout HEK293 Cell Line | EDJ-KQ701 | Human | 5598 | Details Get a Quote |
| MAPK7 Knockout HeLa Cell Line | EDJ-KQ18087 | Human | 5598 | Details Get a Quote |
| MAPK7 Knockout A-549 Cell Line | EDJ-KQ19281 | Human | 5598 | Details Get a Quote |
| MAPK7 Knockout HCT 116 Cell Line | EDJ-KQ19282 | Human | 5598 | Details Get a Quote |
| MAPK7 (p.D200A) Point Mutation in Ishikawa Cell Line | EDC07573 | Human | 5598 | Details Get a Quote |
| MAPK7 Knockout HAP1 Cell Line | EDC07791 | Human | 5598 | Details Get a Quote |
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