MAPK6 (Mitogen-Activated Protein Kinase 6)
A member of the MAP kinase family involved in cell proliferation, differentiation, and stress response.
Gene Information Card
| Symbol | MAPK6 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q21.2 |
| NCBI Gene ID | 5597 ncbi.nlm.nih.gov/gene/5597 |
| Ensembl ID | ENSG00000169908 |
| UniProt ID | Q16659 |
| OMIM ID | 602904 |
| HGNC ID | 6879 |
| Aliases | ERK3, p97MAPK, MAPK6_HUMAN |
Description
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MAPK6 overexpression or mutation may promote cell proliferation and survival through altered kinase activity. | COSMIC, ClinVar |
| Developmental disorders | Rare variants in MAPK6 have been associated with intellectual disability and growth abnormalities. | ClinVar, OMIM |
| Immune dysfunction | MAPK6 regulates cytokine production and T-cell activation; dysregulation linked to inflammatory conditions. | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Lung | 15.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 10.7 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression in embryonic kidney cells |
| HeLa | 14.2 | Moderate expression in cervical cancer cells |
| A549 | 11.8 | Moderate expression in lung cancer cells |
| MCF7 | 9.3 | Low expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Unknown functional effect; reported in ClinVar |
| c.789_790insA (p.Glu264Argfs*12) | Frameshift | <0.01% | Likely loss of function |
| c.1567G>A (p.Glu523Lys) | Missense | <0.1% | Reported in COSMIC; potential gain of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the kinase domain are predicted to cause loss of function.
Gain of Function (GOF)
Missense mutations in the activation loop (e.g., p.Glu523Lys) may enhance kinase activity.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK6 (mitogen-activated protein kinase 6)
• also known as ERK3
• is a member of the mitogen-activated protein kinase (MAPK) family. It encodes a 721-amino acid protein that functions as a serine/threonine kinase involved in cell cycle regulation
• differentiation
• and stress response. Unlike classical MAPKs
• ERK3 has a unique C-terminal extension and is regulated by atypical mechanisms. MAPK6 is expressed in various tissues and has been implicated in cancer
• developmental disorders
• and immune function.
• MAPK signaling pathway (KEGG: hsa04010)
• ErbB signaling pathway (KEGG: hsa04012)
• Focal adhesion (KEGG: hsa04510)
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• MAPK6 (ERK3) is a 721-amino acid serine/threonine kinase with a unique C-terminal extension. It is activated by atypical mechanisms involving phosphorylation by upstream kinases such as PAK1. ERK3 regulates cell cycle progression
• differentiation
• and stress responses. It is widely expressed
• with highest levels in testis and brain. Dysregulation of MAPK6 is linked to cancer and developmental disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK6 Knockout HEK293 Cell Line | EDJ-KQ50542 | Human | 5597 | Details Get a Quote |
| MAPK6 Knockout HeLa Cell Line | EDJ-KQ54215 | Human | 5597 | Details Get a Quote |
| MAPK6 Knockout A-549 Cell Line | EDJ-KQ62709 | Human | 5597 | Details Get a Quote |
| MAPK6 Knockout HCT 116 Cell Line | EDJ-KQ71181 | Human | 5597 | Details Get a Quote |
| MAPK6 Knockout HAP1 Cell Line | EDC08099 | Human | 5597 | Details Get a Quote |
