MAPK3 (Mitogen-Activated Protein Kinase 3)
A key component of the MAPK/ERK signaling pathway involved in cell proliferation, differentiation, and survival.
Gene Information Card
| Symbol | MAPK3 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 5595 ncbi.nlm.nih.gov/gene/5595 |
| Ensembl ID | ENSG00000102882 |
| UniProt ID | P27361 |
| OMIM ID | 601795 |
| HGNC ID | 6877 |
| Aliases | ERK1, p44MAPK, p44-ERK1, PRKM3 |
Description
MAPK3 (Mitogen-Activated Protein Kinase 3) encodes a member of the MAP kinase family, also known as extracellular signal-regulated kinase 1 (ERK1). This protein integrates signals from growth factors, cytokines, and stress stimuli, phosphorylating downstream targets to regulate cell cycle progression, differentiation, transcription, and apoptosis. MAPK3 is ubiquitously expressed and is a central node in the RAS-RAF-MEK-ERK cascade.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Constitutive activation via upstream mutations (e.g., BRAF V600E) or MAPK3 amplification drives uncontrolled proliferation. | COSMIC; PMID: 12460918 |
| Cardiovascular hypertrophy | Sustained ERK1/2 activation promotes pathological cardiac remodeling. | PMID: 17667937 |
| Neurodegenerative disorders | Dysregulated ERK signaling contributes to tau hyperphosphorylation in Alzheimer disease. | PMID: 15689429 |
| Noonan syndrome | Rare germline MAPK3 variants may alter RAS-MAPK signaling. | ClinVar; PMID: 27159400 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Heart | 8.3 | Medium |
| Liver | 6.1 | Medium |
| Lung | 7.8 | Medium |
| Kidney | 9.2 | Medium |
| Testis | 15.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical carcinoma |
| A549 | 11.5 | Lung adenocarcinoma |
| HEK293 | 13.0 | Embryonic kidney |
| MCF7 | 10.8 | Breast adenocarcinoma |
| K562 | 9.4 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.113G>A (p.Gly38Asp) | Missense | <0.1% | Reported in Noonan syndrome; potential gain-of-function |
| c.382C>T (p.Arg128Trp) | Missense | <0.1% | Uncertain significance; ClinVar |
| Amplification | Copy number gain | Variable | Observed in breast and lung cancers; COSMIC |
Mutation functional classification
Loss of Function (LOF)
Rare; complete loss is embryonic lethal in model organisms.
Gain of Function (GOF)
Common in cancer; point mutations or overexpression lead to constitutive ERK signaling.
Dominant Negative (DN)
Engineered mutants (e.g., K71R) block ERK activation; not reported in natural disease.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• RAS signaling pathway (KEGG: hsa04014)
• ErbB signaling pathway (KEGG: hsa04012)
• Focal adhesion (KEGG: hsa04510)
• Neurotrophin signaling pathway (KEGG: hsa04722)
Protein Summary
MAPK3 (ERK1) is a 44 kDa serine/threonine kinase that, together with ERK2, mediates signal transduction from cell surface receptors to the nucleus. It is activated by MEK1/2 via dual phosphorylation on Thr202 and Tyr204. ERK1 phosphorylates hundreds of substrates including transcription factors (ELK1, c-Fos), kinases (RSK), and cytoskeletal proteins. Its activity is tightly regulated; dysregulation is a hallmark of many cancers and developmental disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK3 Knockout HEK293 Cell Line | EDJ-KQ391 | Human | 5595 | Details Get a Quote |
| MAPK3 Knockout A-549 Cell Line | EDJ-KQ18605 | Human | 5595 | Details Get a Quote |
| MAPK3 Knockout HCT 116 Cell Line | EDJ-KQ18606 | Human | 5595 | Details Get a Quote |
| MAPK3 Knockout HeLa Cell Line | EDJ-KQ18607 | Human | 5595 | Details Get a Quote |
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