MAPK15: Mitogen-Activated Protein Kinase 15
Atypical MAP Kinase Involved in Cellular Stress Response and Ciliogenesis
Gene Information Card
| Symbol | MAPK15 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.3 |
| NCBI Gene ID | 225689 ncbi.nlm.nih.gov/gene/225689 |
| Ensembl ID | ENSG00000181085 |
| UniProt ID | Q8TD08 |
| OMIM ID | 608448 |
| HGNC ID | 24667 |
| Aliases | ERK7, ERK8, MAPK15_HUMAN |
Description
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MAPK15 overexpression or mutation may promote tumorigenesis via enhanced cell proliferation and survival | COSMIC, PubMed |
| Ciliopathies | MAPK15 regulates cilia formation; dysregulation may contribute to ciliary dysfunction | PubMed |
| Neurodegenerative diseases | MAPK15 modulates autophagy and protein aggregation; potential role in Alzheimer's and Parkinson's | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.2 | Cervical cancer cell line |
| HEK293 | 9.5 | Embryonic kidney cells |
| A549 | 7.8 | Lung cancer cell line |
| MCF7 | 6.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.113G>A (p.Arg38Gln) | Missense | <0.1% | Unknown functional impact |
| c.487C>T (p.Pro163Ser) | Missense | <0.1% | Potential loss of kinase activity |
| c.1024A>G (p.Thr342Ala) | Missense | <0.1% | Altered substrate binding |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain (e.g., p.Pro163Ser) may reduce catalytic activity.
Gain of Function (GOF)
Overexpression or activating mutations (e.g., p.Arg38Gln) may enhance downstream signaling.
Dominant Negative (DN)
Not well characterized; some C-terminal truncations may act dominant-negatively.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 | • GO:0005524 |
| • GO:0006468 | • GO:0007049 |
| • GO:0030030 | • GO:0006974 |
Pathways
• MAPK15 (also known as ERK7 or ERK8) is an atypical member of the mitogen-activated protein kinase (MAPK) family. Unlike classical MAPKs
• MAPK15 contains a unique C-terminal extension that mediates its localization and function. It is activated by cellular stresses
• growth factors
• and DNA damage
• and plays key roles in ciliogenesis
• autophagy
• cell cycle progression
• and the DNA damage response. MAPK15 is widely expressed and has been implicated in cancer
• neurodegenerative disorders
• and ciliopathies.
• MAPK signaling pathway
• Autophagy
• DNA damage response
• Ciliogenesis
• MAPK15 is a 544-amino acid protein with a typical kinase domain and a unique C-terminal extension that contains a nuclear localization signal and a ciliary targeting motif. It is activated by oxidative stress
• serum starvation
• and DNA damage. MAPK15 phosphorylates substrates involved in autophagy (e.g.
• ULK1)
• cilia formation (e.g.
• CEP164)
• and cell cycle regulation. Its activity is regulated by autophosphorylation and interaction with scaffold proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK15 Knockout HEK293 Cell Line | EDJ-KQ9257 | Human | 225689 | Details Get a Quote |
| MAPK15 Knockout HeLa Cell Line | EDJ-KQ34614 | Human | 225689 | Details Get a Quote |
| MAPK15 Knockout HCT 116 Cell Line | EDJ-KQ35860 | Human | 225689 | Details Get a Quote |
| MAPK15 Knockout A-549 Cell Line | EDJ-KQ67675 | Human | 225689 | Details Get a Quote |
| MAPK15 Knockout HAP1 Cell Line | EDC08200 | Human | 225689 | Details Get a Quote |
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