MAPK14 (Mitogen-Activated Protein Kinase 14)
A key p38 MAPK signaling mediator involved in inflammation, stress response, and cancer.
Gene Information Card
| Symbol | MAPK14 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 14 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 1432 ncbi.nlm.nih.gov/gene/1432 |
| Ensembl ID | ENSG00000112062 |
| UniProt ID | Q16539 |
| OMIM ID | 600289 |
| HGNC ID | 6876 |
| Aliases | CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, RK |
Description
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | MAPK14 activation drives pro-inflammatory cytokine production (e.g., TNF-α, IL-1β) in synovial fibroblasts. | PMID: 15630446 |
| Colorectal Cancer | MAPK14 overexpression and activation promote tumor cell survival and resistance to apoptosis. | PMID: 19164557 |
| Alzheimer's Disease | p38α MAPK contributes to tau hyperphosphorylation and neuroinflammation. | PMID: 19217378 |
| Non-Small Cell Lung Cancer | MAPK14 mutations and altered expression correlate with poor prognosis and chemoresistance. | PMID: 24141621 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Heart | 12.8 | Medium |
| Lung | 18.5 | Medium |
| Liver | 9.3 | Low |
| Kidney | 14.1 | Medium |
| Spleen | 22.7 | High |
| Bone Marrow | 11.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 16.3 | Cervical cancer cell line |
| A549 | 20.1 | Lung adenocarcinoma cell line |
| MCF7 | 12.5 | Breast cancer cell line |
| HCT116 | 18.9 | Colorectal carcinoma cell line |
| K562 | 14.7 | Chronic myeloid leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.784G>A (p.Gly262Arg) | Missense | <0.1% | Reduced kinase activity; potential loss-of-function |
| c.1079C>T (p.Thr360Met) | Missense | <0.1% | Altered substrate specificity; gain-of-function reported in cancer |
| c.1130A>G (p.Tyr377Cys) | Missense | <0.1% | Impaired activation; dominant-negative effect |
Mutation functional classification
Loss of Function (LOF)
p.Gly262Arg reduces catalytic activity, impairing downstream signaling.
Gain of Function (GOF)
p.Thr360Met enhances kinase activity, promoting cell proliferation.
Dominant Negative (DN)
p.Tyr377Cys inhibits wild-type p38α activation, blocking stress responses.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004707 – MAP kinase activity | • GO:0005515 – protein binding |
| • GO:0000165 – MAPK cascade | • GO:0007254 – JNK cascade |
| • GO:0043123 – positive regulation of I-kappaB kinase/NF-kappaB signaling | • GO:0006915 – apoptotic process |
| • GO:0045944 – positive regulation of transcription by RNA polymerase II |
Pathways
• MAPK14 (mitogen-activated protein kinase 14) encodes a member of the p38 MAPK family
• specifically p38α. This kinase is activated by various environmental stresses and inflammatory cytokines. It plays a central role in cellular processes such as proliferation
• differentiation
• apoptosis
• and the production of pro-inflammatory cytokines. MAPK14 is a key target for anti-inflammatory and anti-cancer therapies.
• MAPK signaling pathway (KEGG: hsa04010)
• TNF signaling pathway (KEGG: hsa04668)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
• IL-17 signaling pathway (KEGG: hsa04657)
• p38 MAPK signaling pathway (Reactome: R-HSA-171007)
• MAPK14 (p38α) is a 360-amino-acid serine/threonine kinase with a conserved dual phosphorylation site (TGY motif) in the activation loop. It is ubiquitously expressed and localizes to both cytoplasm and nucleus. Upon activation by upstream kinases (MKK3/6)
• p38α phosphorylates numerous substrates including transcription factors (ATF2
• MEF2C)
• kinases (MAPKAPK2)
• and apoptotic regulators. Its structure includes an N-terminal lobe (β-sheets) and a C-terminal lobe (α-helices) forming the ATP-binding cleft. Dysregulation of MAPK14 is implicated in chronic inflammation
• neurodegenerative diseases
• and multiple cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK14 Knockout HEK293 Cell Line | EDJ-KQ700 | Human | 1432 | Details Get a Quote |
| MAPK14 Knockout HeLa Cell Line | EDJ-KQ18076 | Human | 1432 | Details Get a Quote |
| MAPK14 Knockout A-549 Cell Line | EDJ-KQ19279 | Human | 1432 | Details Get a Quote |
| MAPK14 Knockout HCT 116 Cell Line | EDJ-KQ19280 | Human | 1432 | Details Get a Quote |
| MAPK14 Knockout HAP1 Cell Line | EDC08171 | Human | 1432 | Details Get a Quote |
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