MAPK13: Mitogen-Activated Protein Kinase 13
A p38 MAP Kinase Involved in Inflammation, Cell Differentiation, and Cancer
Gene Information Card
| Symbol | MAPK13 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 5603 ncbi.nlm.nih.gov/gene/5603 |
| Ensembl ID | ENSG00000156711 |
| UniProt ID | O15264 |
| OMIM ID | 602896 |
| HGNC ID | 6874 |
| Aliases | SAPK4, p38delta, PRKM13, p38-2 |
Description
MAPK13 (mitogen-activated protein kinase 13) encodes a member of the p38 MAP kinase family (p38 delta). This kinase is activated by various environmental stresses and pro-inflammatory cytokines. It plays a role in cell differentiation, apoptosis, and inflammatory responses. MAPK13 is involved in the regulation of transcription factors and downstream signaling cascades, and its dysregulation has been implicated in cancer, inflammatory diseases, and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered MAPK13 expression and mutations affect cell proliferation and survival | COSMIC, ClinVar |
| Inflammatory diseases | MAPK13 regulates pro-inflammatory cytokine production | NCBI Gene, UniProt |
| Psoriasis | Increased MAPK13 expression in psoriatic skin lesions | OMIM 602896 |
| Rheumatoid arthritis | MAPK13 contributes to synovial inflammation | UniProt, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Skin | 18.3 | High |
| Esophagus | 15.1 | High |
| Spleen | 8.2 | Low |
| Bone marrow | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 14.2 | High expression |
| HaCaT (keratinocyte) | 20.1 | Very high expression |
| THP-1 (monocyte) | 9.8 | Moderate expression |
| HEK293 (embryonic kidney) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Gly170Arg | Missense | 0.02% | Unknown functional effect |
| p.Arg173Cys | Missense | 0.01% | Potential loss of function |
| p.Thr183Met | Missense | 0.005% | Unknown |
| p.Glu43Lys | Missense | 0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
p.Arg173Cys may reduce kinase activity based on structural homology.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in major databases.
Dominant Negative (DN)
No dominant-negative mutations described for MAPK13.
View complete mutation data：
Gene Ontology (GO)
Pathways
• p38 MAPK signaling pathway (KEGG: hsa04010)
• MAPK signaling pathway (KEGG: hsa04010)
• TNF signaling pathway (KEGG: hsa04668)
• IL-17 signaling pathway (KEGG: hsa04657)
Protein Summary
MAPK13 (p38 delta) is a 365-amino acid serine/threonine protein kinase with a molecular weight of approximately 41 kDa. It contains a conserved kinase domain and a TGY dual phosphorylation motif essential for activation. The protein is predominantly cytoplasmic but can translocate to the nucleus upon stimulation. It phosphorylates downstream targets including transcription factors (e.g., ATF2, MEF2C) and other kinases, regulating stress responses, inflammation, and cell differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAPK13 Knockout HEK293 Cell Line | EDJ-KQ699 | Human | 5603 | Details Get a Quote |
| MAPK13 Knockout HCT 116 Cell Line | EDJ-KQ19278 | Human | 5603 | Details Get a Quote |
| MAPK13 Knockout HeLa Cell Line | EDJ-KQ54217 | Human | 5603 | Details Get a Quote |
| MAPK13 Knockout A-549 Cell Line | EDJ-KQ62711 | Human | 5603 | Details Get a Quote |
