MAP9 Gene (Microtubule Associated Protein 9)
Comprehensive genomic and functional analysis of MAP9, a microtubule-associated protein involved in cell cycle regulation and cancer.
Gene Information Card
| Symbol | MAP9 |
|---|---|
| Full Name | Microtubule Associated Protein 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q32.1 |
| NCBI Gene ID | 79884 ncbi.nlm.nih.gov/gene/79884 |
| Ensembl ID | ENSG00000164104 |
| UniProt ID | Q9H0H5 |
| OMIM ID | 609442 |
| HGNC ID | 26123 |
| Aliases | ASAP, C4orf6, MGC12966 |
Description
MAP9 (Microtubule Associated Protein 9) encodes a protein that binds to microtubules and is involved in spindle formation and chromosome segregation during mitosis. It is also implicated in cell cycle progression and has been associated with various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression and mutations may affect microtubule dynamics and cell division, contributing to tumorigenesis. | PMID: 21798872 |
| Colorectal cancer | MAP9 overexpression correlates with poor prognosis; may promote proliferation via microtubule stabilization. | PMID: 25605248 |
| Hepatocellular carcinoma | Downregulation of MAP9 associated with aggressive tumor features and reduced survival. | PMID: 27663420 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Medium |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Breast | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| MCF7 | 8.7 | Breast cancer cell line |
| HepG2 | 5.4 | Liver cancer cell line |
| A549 | 4.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072C>T (p.Arg358Trp) | Missense | <0.01% | Unknown; predicted damaging by SIFT |
| c.1456G>A (p.Gly486Arg) | Missense | <0.01% | Unknown; predicted benign |
| c.1789_1790insA (p.Thr597Asnfs*2) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr597Asnfs*2) likely result in truncated protein and loss of microtubule binding.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • spindle organization |
| • cell cycle | • mitosis |
| • cytoskeleton |
Pathways
• Cell Cycle
• Mitotic
• Microtubule cytoskeleton organization
Protein Summary
MAP9 is a 647-amino acid protein that localizes to the mitotic spindle and centrosomes. It stabilizes microtubules and is essential for proper chromosome segregation. The protein contains a microtubule-binding domain and interacts with other spindle-associated proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP9 Knockout HEK293 Cell Line | EDJ-KQ13410 | Human | 79884 | Details Get a Quote |
| MAP9 Knockout A-549 Cell Line | EDJ-KQ44146 | Human | 79884 | Details Get a Quote |
| MAP9 Knockout HeLa Cell Line | EDJ-KQ57250 | Human | 79884 | Details Get a Quote |
| MAP9 Knockout HCT 116 Cell Line | EDJ-KQ74182 | Human | 79884 | Details Get a Quote |
