MAP7 Gene: Microtubule-Associated Protein 7
A comprehensive biomedical resource for MAP7, including gene structure, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | MAP7 |
|---|---|
| Full Name | microtubule-associated protein 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q23.3 |
| NCBI Gene ID | 9053 ncbi.nlm.nih.gov/gene/9053 |
| Ensembl ID | ENSG00000112549 |
| UniProt ID | Q14244 |
| OMIM ID | 600754 |
| HGNC ID | 6869 |
| Aliases | E-MAP-115, EMAP115, MDP7 |
Description
MAP7 (microtubule-associated protein 7) encodes a protein that binds to microtubules and stabilizes them. It is involved in microtubule organization, cell division, and intracellular transport. MAP7 is expressed in multiple tissues and has been implicated in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | MAP7 overexpression may promote microtubule stability and cell proliferation; altered expression linked to tumor progression. | COSMIC, literature |
| Neurodegenerative disorders | MAP7 dysfunction may affect axonal transport and microtubule dynamics, contributing to neuronal degeneration. | OMIM, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.2 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.8 | Low |
| Testis | 15.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.5 | Cervical cancer cell line |
| A549 | 7.8 | Lung cancer cell line |
| HEK293 | 9.2 | Embryonic kidney cell line |
| SH-SY5Y | 14.1 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.1% | Unknown |
| c.567_568insA | frameshift | <0.1% | Loss of function |
| c.890G>A | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein and loss of microtubule binding.
Gain of Function (GOF)
Not well characterized; some missense variants may enhance microtubule stability.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • microtubule cytoskeleton organization |
| • cell division | • intracellular transport |
| • cytoplasm |
Pathways
• Microtubule cytoskeleton regulation
• Cell cycle
Protein Summary
The MAP7 protein (E-MAP-115) is a 115 kDa microtubule-associated protein that stabilizes microtubules and promotes their assembly. It contains a microtubule-binding domain and is involved in mitotic spindle organization and interphase microtubule network maintenance. MAP7 is expressed in various tissues and cell lines, with highest levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP7D1 Knockout HEK293 Cell Line | EDJ-KQ2371 | Human | 55700 | Details Get a Quote |
| MAP7 Knockout HEK293 Cell Line | EDJ-KQ6445 | Human | 9053 | Details Get a Quote |
| MAP7D2 Knockout HEK293 Cell Line | EDJ-KQ11844 | Human | 256714 | Details Get a Quote |
| GIMAP7 Knockout HEK293 Cell Line | EDJ-KQ13594 | Human | 168537 | Details Get a Quote |
| MAP7D3 Knockout HEK293 Cell Line | EDJ-KQ14197 | Human | 79649 | Details Get a Quote |
| MAP7D3 Knockout A-549 Cell Line | EDJ-KQ44143 | Human | 79649 | Details Get a Quote |
| MAP7D3 Knockout HCT 116 Cell Line | EDJ-KQ44144 | Human | 79649 | Details Get a Quote |
| MAP7D3 Knockout HeLa Cell Line | EDJ-KQ44145 | Human | 79649 | Details Get a Quote |
| MAP7D1 Knockout HeLa Cell Line | EDJ-KQ21508 | Human | 55700 | Details Get a Quote |
| MAP7D1 Knockout A-549 Cell Line | EDJ-KQ22829 | Human | 55700 | Details Get a Quote |
| MAP7D1 Knockout HCT 116 Cell Line | EDJ-KQ22830 | Human | 55700 | Details Get a Quote |
| MAP7 Knockout A-549 Cell Line | EDJ-KQ30507 | Human | 9053 | Details Get a Quote |
| MAP7 Knockout HCT 116 Cell Line | EDJ-KQ30508 | Human | 9053 | Details Get a Quote |
| MAP7 Knockout HeLa Cell Line | EDJ-KQ30509 | Human | 9053 | Details Get a Quote |
| MAP7D2 Knockout A-549 Cell Line | EDJ-KQ40269 | Human | 256714 | Details Get a Quote |
Displaying Records 1 To 15 Of 20 Records
