MAP4 Gene - Microtubule Associated Protein 4
A comprehensive guide to MAP4, its function, expression, and role in disease.
Gene Information Card
| Symbol | MAP4 |
|---|---|
| Full Name | Microtubule Associated Protein 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 4134 ncbi.nlm.nih.gov/gene/4134 |
| Ensembl ID | ENSG00000147889 |
| UniProt ID | P27816 |
| OMIM ID | 157132 |
| HGNC ID | 6869 |
| Aliases | MAP-4, MTAP4 |
Description
MAP4 (Microtubule Associated Protein 4) is a protein-coding gene that encodes a member of the microtubule-associated protein family. The encoded protein stabilizes microtubules and promotes their assembly, playing a critical role in cell division, intracellular transport, and cytoskeletal organization. MAP4 is ubiquitously expressed and is involved in various cellular processes including mitosis and neuronal differentiation. Alterations in MAP4 expression and function have been implicated in cancer, neurodegenerative diseases, and other disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered MAP4 expression affects microtubule dynamics, influencing cell proliferation and response to chemotherapeutics like taxanes. | COSMIC, ClinVar |
| Neurodegenerative diseases | MAP4 dysfunction may contribute to tau pathology and microtubule destabilization in conditions such as Alzheimer's disease. | OMIM, NCBI |
| Developmental disorders | Rare variants in MAP4 have been associated with neurodevelopmental phenotypes. | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Lung | 10.1 | Medium |
| Liver | 7.2 | Low |
| Kidney | 9.8 | Medium |
| Testis | 15.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| A549 | 11.5 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HEK293 | 13.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional impact |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
| c.890C>T (p.Thr297Met) | Missense | 0.02% | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, potentially disrupting microtubule stabilization.
Gain of Function (GOF)
Not well characterized; some missense variants may alter microtubule binding affinity.
Dominant Negative (DN)
No dominant negative mutations have been confirmed for MAP4.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • microtubule cytoskeleton organization |
| • mitotic spindle assembly | • protein stabilization |
| • intracellular transport |
Pathways
• Microtubule dynamics
• Cell cycle - mitosis
• Tau pathology in Alzheimer's disease
Protein Summary
Microtubule-associated protein 4 (MAP4) is a 1,152-amino acid protein that binds to and stabilizes microtubules. It contains a microtubule-binding domain and a projection domain. MAP4 is ubiquitously expressed and regulates microtubule dynamics during cell division and interphase. It interacts with tau and other MAPs, and its phosphorylation by various kinases modulates its activity. MAP4 is implicated in cancer cell resistance to microtubule-targeting drugs and in neurodegenerative tauopathies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP4K4 Knockout HEK293 Cell Line | EDJ-KQ100 | Human | 9448 | Details Get a Quote |
| MAP4K3 Knockout HEK293 Cell Line | EDJ-KQ190 | Human | 8491 | Details Get a Quote |
| MAP4K1 Knockout HEK293 Cell Line | EDJ-KQ696 | Human | 11184 | Details Get a Quote |
| MAP4K2 Knockout HEK293 Cell Line | EDJ-KQ1878 | Human | 5871 | Details Get a Quote |
| MAP4 Knockout HEK293 Cell Line | EDJ-KQ5175 | Human | 4134 | Details Get a Quote |
| MAP4K5 Knockout HEK293 Cell Line | EDJ-KQ7322 | Human | 11183 | Details Get a Quote |
| GIMAP4 Knockout HEK293 Cell Line | EDJ-KQ13593 | Human | 55303 | Details Get a Quote |
| MAP4K2 Knockout A-549 Cell Line | EDJ-KQ23123 | Human | 5871 | Details Get a Quote |
| MAP4K2 Knockout HCT 116 Cell Line | EDJ-KQ23125 | Human | 5871 | Details Get a Quote |
| MAP4K2 Knockout HeLa Cell Line | EDJ-KQ23126 | Human | 5871 | Details Get a Quote |
| MAP4 Knockout A-549 Cell Line | EDJ-KQ28160 | Human | 4134 | Details Get a Quote |
| MAP4 Knockout HCT 116 Cell Line | EDJ-KQ28161 | Human | 4134 | Details Get a Quote |
| MAP4 Knockout HeLa Cell Line | EDJ-KQ28162 | Human | 4134 | Details Get a Quote |
| MAP4K3 Knockout A-549 Cell Line | EDJ-KQ19268 | Human | 8491 | Details Get a Quote |
| MAP4K3 Knockout HCT 116 Cell Line | EDJ-KQ19270 | Human | 8491 | Details Get a Quote |
Displaying Records 1 To 15 Of 30 Records
