MAP3K2
Mitogen-Activated Protein Kinase Kinase Kinase 2
Gene Information Card
| Symbol | MAP3K2 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 10746 ncbi.nlm.nih.gov/gene/10746 |
| Ensembl ID | ENSG00000134138 |
| UniProt ID | Q9Y2U5 |
| OMIM ID | 601334 |
| HGNC ID | 6855 |
| Aliases | MEKK2, MAPKKK2 |
Description
MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) encodes a serine/threonine kinase that functions as a MAP3K in the MAPK signaling cascade. It specifically activates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. The protein contains a PB1 domain that mediates interactions with other signaling proteins and is involved in cellular responses to growth factors, cytokines, and stress stimuli.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MAP3K2 mutations and overexpression can dysregulate MAPK signaling, promoting cell proliferation and survival | COSMIC; ClinVar |
| Cardiovascular diseases | Altered MAP3K2 activity may contribute to cardiac hypertrophy and vascular remodeling | NCBI Gene; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 15.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 18.7 | Medium |
| Testis | 22.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 20.1 | Embryonic kidney cells |
| HeLa | 15.8 | Cervical cancer cells |
| A549 | 12.3 | Lung cancer cells |
| MCF7 | 9.7 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Glu207Lys | Missense | <1% | Unknown functional impact |
| p.Arg441* | Nonsense | <1% | Likely loss of function |
| p.Val580Met | Missense | <1% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg441*) are predicted to truncate the kinase domain, reducing or abolishing catalytic activity.
Gain of Function (GOF)
Some missense mutations in the kinase domain may enhance activity, but specific gain-of-function variants are not well characterized.
Dominant Negative (DN)
No dominant-negative mutations have been formally described for MAP3K2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• JNK cascade (Reactome: R-HSA-450294)
• ERK5 cascade (Reactome: R-HSA-198753)
Protein Summary
MAP3K2 (MEKK2) is a 619-amino-acid serine/threonine kinase with an N-terminal PB1 domain and a C-terminal kinase domain. It acts as a MAP3K that phosphorylates and activates MKK5 and MKK7, leading to ERK5 and JNK activation, respectively. The protein is widely expressed and plays roles in cell proliferation, differentiation, and stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP3K2 Knockout HEK293 Cell Line | EDJ-KQ689 | Human | 10746 | Details Get a Quote |
| MAP3K20 Knockout HEK293 Cell Line | EDJ-KQ690 | Human | 51776 | Details Get a Quote |
| MAP3K21 Knockout HEK293 Cell Line | EDJ-KQ10092 | Human | 84451 | Details Get a Quote |
| MAP3K2 Knockout A-549 Cell Line | EDJ-KQ18131 | Human | 10746 | Details Get a Quote |
| MAP3K21 Knockout A-549 Cell Line | EDJ-KQ35936 | Human | 84451 | Details Get a Quote |
| MAP3K21 Knockout HCT 116 Cell Line | EDJ-KQ37168 | Human | 84451 | Details Get a Quote |
| MAP3K21 Knockout HeLa Cell Line | EDJ-KQ37169 | Human | 84451 | Details Get a Quote |
| MAP3K2 Knockout HCT 116 Cell Line | EDJ-KQ19248 | Human | 10746 | Details Get a Quote |
| MAP3K2 Knockout HeLa Cell Line | EDJ-KQ19249 | Human | 10746 | Details Get a Quote |
| MAP3K20 Knockout A-549 Cell Line | EDJ-KQ19250 | Human | 51776 | Details Get a Quote |
| MAP3K20 Knockout HCT 116 Cell Line | EDJ-KQ19251 | Human | 51776 | Details Get a Quote |
| MAP3K20 Knockout HeLa Cell Line | EDJ-KQ19252 | Human | 51776 | Details Get a Quote |
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