MAP3K19
Mitogen-Activated Protein Kinase Kinase Kinase 19
Gene Information Card
| Symbol | MAP3K19 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 19 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 80122 ncbi.nlm.nih.gov/gene/80122 |
| Ensembl ID | ENSG00000163082 |
| UniProt ID | Q8IY84 |
| OMIM ID | 617294 |
| HGNC ID | 21721 |
| Aliases | RCK, Ysk4 |
Description
MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a protein-coding gene that encodes a member of the serine/threonine protein kinase family. This kinase is involved in the MAPK signaling cascade, which regulates various cellular processes including proliferation, differentiation, and stress response. MAP3K19 is also known as RCK (Ras and cAMP-dependent protein kinase) and Ysk4. It is expressed in multiple tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MAP3K19 mutations and altered expression may contribute to tumorigenesis through dysregulation of MAPK signaling. | COSMIC database reports mutations in multiple cancer types. |
| Lung adenocarcinoma | Overexpression of MAP3K19 has been observed and may promote cell proliferation. | PubMed studies and TCGA data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 15.2 | Medium |
| Testis | 12.8 | Medium |
| Brain | 8.5 | Low |
| Heart | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 18.5 | High expression |
| HEK293 (embryonic kidney) | 12.3 | Moderate expression |
| HeLa (cervical carcinoma) | 9.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.R782W | Missense | 0.02% (COSMIC) | Unknown functional effect |
| p.E1045K | Missense | 0.01% (COSMIC) | Unknown functional effect |
| c.1234delA | Frameshift deletion | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift deletions and nonsense mutations are predicted to result in loss of kinase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not established.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • MAPK cascade | • signal transduction |
| • protein phosphorylation |
Pathways
• MAPK signaling pathway
• Ras signaling pathway
Protein Summary
MAP3K19 encodes a 1,237-amino acid protein with a serine/threonine kinase domain. It functions as a MAP3K that phosphorylates and activates downstream MAP2Ks, leading to ERK, JNK, or p38 activation. The protein is localized in the cytoplasm and nucleus and is involved in cell growth and stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP3K19 Knockout HEK293 Cell Line | EDJ-KQ9448 | Human | 80122 | Details Get a Quote |
| MAP3K19 Knockout HeLa Cell Line | EDJ-KQ57293 | Human | 80122 | Details Get a Quote |
| MAP3K19 Knockout A-549 Cell Line | EDJ-KQ65801 | Human | 80122 | Details Get a Quote |
| MAP3K19 Knockout HCT 116 Cell Line | EDJ-KQ74225 | Human | 80122 | Details Get a Quote |
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