MAP3K15 Gene - Mitogen-Activated Protein Kinase Kinase Kinase 15
Comprehensive genomic and functional analysis of MAP3K15, a member of the STE kinase family involved in MAPK signaling.
Gene Information Card
| Symbol | MAP3K15 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 15 |
| Gene Type | Protein coding |
| Chromosomal Location | Xp22.13 |
| NCBI Gene ID | 389840 ncbi.nlm.nih.gov/gene/389840 |
| Ensembl ID | ENSG00000180879 |
| UniProt ID | Q6ZN16 |
| OMIM ID | 300849 |
| HGNC ID | 29418 |
| Aliases | ASK3, MAPKKK15 |
Description
MAP3K15 (Mitogen-Activated Protein Kinase Kinase Kinase 15) is a protein-coding gene that belongs to the STE serine/threonine protein kinase family. It encodes a kinase that functions as a MAP3K in the MAPK signaling cascade, potentially activating downstream kinases such as MKK3/MKK6 and p38. MAP3K15 is involved in cellular stress responses and apoptosis. The gene is located on the X chromosome and is predominantly expressed in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered MAP3K15 expression may contribute to tumor progression via dysregulated MAPK signaling; mutations observed in COSMIC | COSMIC |
| Lung cancer | Somatic mutations in MAP3K15 identified; potential role in MAPK pathway activation | COSMIC |
| Colorectal cancer | Missense mutations reported; functional impact under investigation | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Heart | 2.1 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 5.0 | Moderate expression |
| HeLa | 3.2 | Low expression |
| A549 | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.R123W | Missense | 0.02% | Unknown; predicted damaging by SIFT |
| p.G45R | Missense | 0.01% | Unknown; likely benign |
| p.L200P | Missense | 0.005% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • MAP kinase kinase kinase activity |
| • ATP binding | • signal transduction |
| • protein phosphorylation | • MAPK cascade |
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• p38 MAPK signaling pathway
Protein Summary
MAP3K15 encodes a 1,378-amino acid protein with an N-terminal kinase domain and a C-terminal regulatory region. It acts as a MAP3K, phosphorylating and activating MKK3/MKK6, which in turn activate p38 MAPK. The protein is involved in stress-induced signaling and may play a role in neuronal development and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP3K15 Knockout HEK293 Cell Line | EDJ-KQ14195 | Human | 389840 | Details Get a Quote |
| MAP3K15 Knockout A-549 Cell Line | EDJ-KQ42924 | Human | 389840 | Details Get a Quote |
| MAP3K15 Knockout HCT 116 Cell Line | EDJ-KQ44141 | Human | 389840 | Details Get a Quote |
| MAP3K15 Knockout HeLa Cell Line | EDJ-KQ60109 | Human | 389840 | Details Get a Quote |
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