MAP3K11
Mitogen-Activated Protein Kinase Kinase Kinase 11
Gene Information Card
| Symbol | MAP3K11 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 4296 ncbi.nlm.nih.gov/gene/4296 |
| Ensembl ID | ENSG00000173334 |
| UniProt ID | Q16584 |
| OMIM ID | 600050 |
| HGNC ID | 6853 |
| Aliases | MLK3, SPRK, PTK1 |
Description
MAP3K11 (MLK3) is a serine/threonine kinase that activates the JNK and p38 MAPK pathways. It plays roles in cell proliferation, differentiation, apoptosis, and stress responses. Dysregulation is implicated in cancer and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression and activation of MAP3K11 promote cell proliferation and invasion via JNK signaling. | NCBI Gene, COSMIC |
| Prostate cancer | MAP3K11 mutations and altered expression contribute to tumor progression. | COSMIC, ClinVar |
| Neurodegenerative diseases | MAP3K11-mediated JNK activation is involved in neuronal apoptosis in Alzheimer's and Parkinson's. | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Prostate | 9.1 | Low |
| Liver | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 10.2 | Breast cancer cell line |
| PC3 | 11.5 | Prostate cancer cell line |
| SH-SY5Y | 14.0 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Unknown functional effect |
| c.567G>A (p.Glu189Lys) | Missense | <0.1% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair kinase activity.
Gain of Function (GOF)
Not well documented; overexpression in cancer suggests possible gain-of-function.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • MAP kinase kinase kinase activity | • protein serine/threonine kinase activity |
| • JNK cascade | • apoptotic process |
| • positive regulation of transcription by RNA polymerase II |
Pathways
• MAPK signaling pathway
• JNK signaling pathway
• p38 MAPK signaling pathway
• TNF signaling pathway
Protein Summary
MAP3K11 (MLK3) is a 847-amino acid serine/threonine kinase with an SH3 domain, a kinase domain, and a leucine zipper motif. It activates the JNK and p38 pathways, regulating cell survival, differentiation, and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP3K11 Knockout HEK293 Cell Line | EDJ-KQ686 | Human | 4296 | Details Get a Quote |
| MAP3K11 Knockout HCT 116 Cell Line | EDJ-KQ18126 | Human | 4296 | Details Get a Quote |
| MAP3K11 Knockout A-549 Cell Line | EDJ-KQ19238 | Human | 4296 | Details Get a Quote |
| MAP3K11 Knockout HeLa Cell Line | EDJ-KQ19240 | Human | 4296 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
