MAP3K10 Gene
Mitogen-Activated Protein Kinase Kinase Kinase 10
Gene Information Card
| Symbol | MAP3K10 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 4294 ncbi.nlm.nih.gov/gene/4294 |
| Ensembl ID | ENSG00000130758 |
| UniProt ID | Q02779 |
| OMIM ID | 600182 |
| HGNC ID | 6851 |
| Aliases | MLK2, MST, MEKK10, MKN28K |
Description
MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) encodes a member of the serine/threonine protein kinase family, specifically the mixed lineage kinase (MLK) subfamily. This kinase activates the JNK and p38 MAPK pathways through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7. It plays roles in neuronal development, apoptosis, and cell differentiation. Dysregulation is implicated in cancer and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression and activation of JNK pathway promoting cell proliferation | PMID: 21947068 |
| Colorectal cancer | MAP3K10 amplification and increased kinase activity | PMID: 23542345 |
| Neurodegenerative disorders (e.g., Alzheimer's) | Aberrant JNK signaling leading to tau phosphorylation | PMID: 15689429 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Liver | 3.8 | Low |
| Kidney | 2.1 | Low |
| Heart | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Moderate expression |
| HepG2 | 6.5 | High expression |
| SH-SY5Y | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.1786C>T (p.Arg596Trp) | Missense | 0.005% | Potential loss of kinase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain may reduce catalytic activity, impairing JNK signaling.
Gain of Function (GOF)
Amplification or activating mutations (rare) may enhance kinase activity, promoting oncogenic signaling.
Dominant Negative (DN)
Truncating mutations or kinase-dead variants can act as dominant negatives, blocking downstream signaling.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • MAP kinase kinase kinase activity |
| • ATP binding | • JNK cascade |
| • apoptotic process | • positive regulation of transcription by RNA polymerase II |
Pathways
• JNK signaling pathway (KEGG: hsa04010)
• MAPK signaling pathway (KEGG: hsa04010)
• TNF signaling pathway (KEGG: hsa04668)
Protein Summary
MAP3K10 is a 954-amino acid protein containing an N-terminal SH3 domain, a kinase domain, and a C-terminal leucine zipper. It functions as a MAP3K that specifically activates the JNK pathway. The protein is expressed in brain and liver, and its dysregulation contributes to cancer and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP3K10 Knockout HEK293 Cell Line | EDJ-KQ2672 | Human | 4294 | Details Get a Quote |
| MAP3K10 Knockout HCT 116 Cell Line | EDJ-KQ22096 | Human | 4294 | Details Get a Quote |
| MAP3K10 Knockout A-549 Cell Line | EDJ-KQ23464 | Human | 4294 | Details Get a Quote |
| MAP3K10 Knockout HeLa Cell Line | EDJ-KQ23465 | Human | 4294 | Details Get a Quote |
| MAP3K10 Knockout HAP1 Cell Line | EDC08261 | Human | 4294 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
