MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7)
A dual-specificity kinase in the JNK signaling pathway, implicated in cancer, inflammation, and developmental disorders.
Gene Information Card
| Symbol | MAP2K7 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 5609 ncbi.nlm.nih.gov/gene/5609 |
| Ensembl ID | ENSG00000176953 |
| UniProt ID | O14733 |
| OMIM ID | 603014 |
| HGNC ID | 6847 |
| Aliases | MKK7, JNKK2, PRKMK7, SAPKK4, MAPKK7 |
Description
MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) encodes a dual-specificity protein kinase that specifically phosphorylates and activates c-Jun N-terminal kinases (JNKs). It is a key component of the stress-activated protein kinase (SAPK) signaling cascade, responding to cytokines, environmental stress, and growth factors. MAP2K7 is essential for JNK activation and plays critical roles in cell proliferation, differentiation, apoptosis, and inflammation. Dysregulation of MAP2K7 is associated with various cancers, inflammatory diseases, and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression or gain-of-function mutations lead to constitutive JNK activation, promoting cell survival and proliferation. | COSMIC; multiple studies |
| Inflammatory diseases | Enhanced MAP2K7 activity amplifies JNK-mediated pro-inflammatory cytokine production. | NCBI Gene; literature |
| Developmental disorders | Loss-of-function mutations impair JNK signaling, affecting embryonic development and tissue homeostasis. | OMIM; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Medium |
| Brain (cortex) | 6.1 | Low |
| Liver | 4.3 | Low |
| Heart | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 9.5 | Cervical cancer cell line |
| A549 | 7.8 | Lung cancer cell line |
| HEK293 | 6.2 | Embryonic kidney cell line |
| MCF7 | 5.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.625C>T (p.Arg209Trp) | Missense | <1% | Reported in cancer; potential gain-of-function |
| c.371A>G (p.Asn124Ser) | Missense | <1% | Found in developmental disorder; likely loss-of-function |
| c.1072_1073insA | Frameshift | <1% | Truncating; loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the kinase domain, reducing JNK activation.
Gain of Function (GOF)
Missense mutations in the activation loop that increase kinase activity and JNK signaling.
Dominant Negative (DN)
Mutations that produce inactive protein capable of interfering with wild-type MAP2K7 function.
View complete mutation data：
Gene Ontology (GO)
| • MAP kinase kinase activity | • protein serine/threonine kinase activity |
| • JUN kinase kinase activity | • ATP binding |
| • signal transduction | • stress-activated MAPK cascade |
| • positive regulation of JNK cascade | • apoptotic process |
Pathways
• JNK signaling pathway
• MAPK signaling pathway
• TNF signaling pathway
• IL-17 signaling pathway
• Fc epsilon RI signaling pathway
Protein Summary
MAP2K7 (MKK7) is a 419-amino-acid dual-specificity kinase with an N-terminal docking domain and a C-terminal kinase domain. It specifically phosphorylates JNK1, JNK2, and JNK3 on Thr and Tyr residues. The protein is activated by upstream kinases such as MAP3K1/MEKK1 and MAP3K2/MEKK2. MAP2K7 is widely expressed, with highest levels in testis and lymphoid tissues. Its activity is tightly regulated by phosphorylation and protein-protein interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP2K7 Knockout HEK293 Cell Line | EDJ-KQ684 | Human | 5609 | Details Get a Quote |
| MAP2K7 Knockout A-549 Cell Line | EDJ-KQ19233 | Human | 5609 | Details Get a Quote |
| MAP2K7 Knockout HCT 116 Cell Line | EDJ-KQ19234 | Human | 5609 | Details Get a Quote |
| MAP2K7 Knockout HeLa Cell Line | EDJ-KQ19235 | Human | 5609 | Details Get a Quote |
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