MAP2K6
Mitogen-Activated Protein Kinase Kinase 6
Gene Information Card
| Symbol | MAP2K6 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q24.3 |
| NCBI Gene ID | 5608 ncbi.nlm.nih.gov/gene/5608 |
| Ensembl ID | ENSG00000108984 |
| UniProt ID | P52564 |
| OMIM ID | 601254 |
| HGNC ID | 6846 |
| Aliases | MKK6, MEK6, MAPKK6, PRKMK6, SAPKK3 |
Description
MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6) is a dual-specificity protein kinase that specifically phosphorylates and activates p38 MAP kinases (MAPK11, MAPK12, MAPK13, MAPK14) in response to cellular stress and inflammatory cytokines. It acts as a key signal transducer in the p38 MAPK cascade, regulating processes such as cell differentiation, apoptosis, and autophagy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered MAP2K6 expression or mutation may dysregulate p38 signaling, affecting cell proliferation and survival | COSMIC, ClinVar |
| Inflammatory disorders | Aberrant MAP2K6 activity can contribute to chronic inflammation via sustained p38 activation | NCBI Gene, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal Muscle | 10.8 | Medium |
| Brain | 8.2 | Medium |
| Lung | 6.4 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical carcinoma |
| A549 | 11.7 | Lung carcinoma |
| HEK 293 | 9.5 | Embryonic kidney |
| MCF7 | 7.2 | Breast carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Glu207Lys | Missense | <0.1% | Unknown functional impact |
| p.Arg129Cys | Missense | <0.1% | Potential loss of kinase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain (e.g., Arg129Cys) may impair ATP binding or substrate phosphorylation.
Gain of Function (GOF)
Not well documented; activating mutations are rare.
Dominant Negative (DN)
Kinase-dead mutants can act as dominant negatives by sequestering upstream activators.
View complete mutation data：
Gene Ontology (GO)
| • MAP kinase kinase activity | • Protein serine/threonine kinase activity |
| • ATP binding | • Signal transduction |
| • p38 MAPK cascade | • Stress-activated MAPK cascade |
Pathways
• p38 MAPK signaling pathway (KEGG: hsa04010)
• MAPK signaling pathway (KEGG: hsa04010)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
Protein Summary
MAP2K6 (MKK6) is a 334-amino-acid dual-specificity kinase that phosphorylates threonine and tyrosine residues in the activation loop of p38 MAP kinases. It is activated by upstream MAP3Ks (e.g., MEKK3, TAK1) and is essential for stress-induced p38 activation. The protein contains an N-terminal docking domain for substrate recognition and a C-terminal kinase domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP2K6 Knockout HEK293 Cell Line | EDJ-KQ1353 | Human | 5608 | Details Get a Quote |
| MAP2K6 Knockout A-549 Cell Line | EDJ-KQ20828 | Human | 5608 | Details Get a Quote |
| MAP2K6 Knockout HeLa Cell Line | EDJ-KQ20829 | Human | 5608 | Details Get a Quote |
| MAP2K6 Knockout HCT 116 Cell Line | EDJ-KQ71183 | Human | 5608 | Details Get a Quote |
