MAP2K3
Mitogen-Activated Protein Kinase Kinase 3
Gene Information Card
| Symbol | MAP2K3 |
|---|---|
| Full Name | Mitogen-Activated Protein Kinase Kinase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 5606 ncbi.nlm.nih.gov/gene/5606 |
| Ensembl ID | ENSG00000134107 |
| UniProt ID | P46734 |
| OMIM ID | 602315 |
| HGNC ID | 6842 |
| Aliases | MKK3, MEK3, MAPKK3, PRKMK3 |
Description
MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) encodes a dual-specificity protein kinase that phosphorylates and activates p38 MAP kinases (MAPK11, MAPK12, MAPK13, MAPK14) in response to various cellular stresses and cytokines. It is a key component of the MAPK signaling cascade involved in cell differentiation, proliferation, apoptosis, and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of MAP2K3 expression or activity alters p38 signaling, promoting tumorigenesis and metastasis. | COSMIC, NCBI |
| Inflammatory diseases | MAP2K3 mediates pro-inflammatory cytokine production via p38 activation, implicated in rheumatoid arthritis and inflammatory bowel disease. | NCBI, OMIM |
| Cardiovascular diseases | MAP2K3 contributes to cardiac hypertrophy and fibrosis through p38 signaling. | NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Skeletal Muscle | 8.7 | Medium |
| Brain | 6.5 | Low |
| Lung | 9.1 | Medium |
| Liver | 4.2 | Low |
| Kidney | 7.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.5 | Cervical cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| HEK293 | 7.2 | Embryonic kidney cell line |
| MCF7 | 6.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.214G>A (p.Gly72Arg) | Missense | <0.1% | Altered kinase activity; potential gain-of-function |
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Unknown functional effect |
| c.1003_1005del (p.Lys335del) | In-frame deletion | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
In-frame deletions or nonsense mutations that impair kinase activity or protein stability.
Gain of Function (GOF)
Missense mutations that enhance kinase activity or alter substrate specificity.
Dominant Negative (DN)
Mutations that produce inactive protein interfering with wild-type MAP2K3 function.
View complete mutation data：
Gene Ontology (GO)
| • MAP kinase kinase activity | • protein serine/threonine kinase activity |
| • ATP binding | • signal transduction |
| • p38 MAPK cascade | • response to stress |
| • inflammatory response |
Pathways
• p38 MAPK signaling pathway
• Toll-like receptor signaling pathway
• TNF signaling pathway
• IL-17 signaling pathway
• MAPK signaling pathway
Protein Summary
MAP2K3 (MKK3) is a 347-amino acid dual-specificity kinase that specifically activates p38 MAPKs by phosphorylating Thr-Gly-Tyr motifs. It is widely expressed and plays critical roles in stress responses, inflammation, and cell fate decisions. Dysregulation of MAP2K3 is linked to cancer, inflammatory diseases, and cardiovascular disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP2K3 Knockout HEK293 Cell Line | EDJ-KQ681 | Human | 5606 | Details Get a Quote |
| MAP2K3 Knockout A-549 Cell Line | EDJ-KQ19228 | Human | 5606 | Details Get a Quote |
| MAP2K3 Knockout HCT 116 Cell Line | EDJ-KQ19229 | Human | 5606 | Details Get a Quote |
| MAP2K3 Knockout HeLa Cell Line | EDJ-KQ19230 | Human | 5606 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
