MAP2 Gene - Microtubule Associated Protein 2

Comprehensive genomic and functional overview of MAP2, a key neuronal cytoskeletal protein.

Gene Information Card

Symbol MAP2
Full Name Microtubule Associated Protein 2
Gene Type protein-coding
Chromosomal Location 2q34
NCBI Gene ID 4133 ncbi.nlm.nih.gov/gene/4133
Ensembl ID ENSG00000078018
UniProt ID P11137
OMIM ID 157130
HGNC ID 6839
Aliases MAP2A, MAP2B, MAP2C, MAP2D, MTAP2

Description

MAP2 (Microtubule Associated Protein 2) encodes a protein that binds to microtubules and promotes their assembly and stability. It is primarily expressed in neurons, where it plays a critical role in dendrite formation, neuronal polarity, and cytoskeletal organization. Alternative splicing generates multiple isoforms (MAP2A, MAP2B, MAP2C, MAP2D) with distinct developmental and regional expression patterns.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Alzheimer disease MAP2 is a substrate for hyperphosphorylation and cleavage by calpain, contributing to neurofibrillary pathology and dendritic degeneration. PMID: 17088211; NCBI GeneRIF
Schizophrenia Reduced MAP2 expression in prefrontal cortex and hippocampus is associated with dendritic spine loss and synaptic dysfunction. PMID: 11597303; NCBI GeneRIF
Epilepsy Altered MAP2 phosphorylation and proteolysis in hippocampal neurons following status epilepticus, linked to dendritic remodeling. PMID: 12684468; NCBI GeneRIF

Expression Profile

Tissue Expression
Tissue nTPM level
Brain 78.5 High
Testis 1.2 Low
Adrenal Gland 0.8 Low
Heart 0.3 Not detected
Liver 0.1 Not detected
Cell Line Expression
Cell Line nTPM Notes
SH-SY5Y 45.2 Neuroblastoma cell line; high MAP2 expression
U-87 MG 12.8 Glioblastoma cell line; moderate expression
HEK 293 0.5 Low expression; non-neuronal
HeLa 0.2 Not detected
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.1234C>T (p.Arg412Cys) Missense <0.01% Unknown; predicted to affect microtubule binding
c.2567_2569del (p.Lys856del) In-frame deletion <0.01% Unknown; may alter isoform stability
c.3456G>A (p.Trp1152*) Nonsense <0.01% Loss of function; predicted to cause nonsense-mediated decay
Mutation functional classification

Loss of Function (LOF)

Nonsense and frameshift variants leading to truncated protein or mRNA decay.

Gain of Function (GOF)

Not reported for MAP2.

Dominant Negative (DN)

Not reported for MAP2.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/4133
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MAP2

Gene Ontology (GO)

• microtubule binding (GO:0008017) • structural constituent of cytoskeleton (GO:0005200)
• microtubule cytoskeleton organization (GO:0000226) • dendrite morphogenesis (GO:0048813)
• neuron projection development (GO:0031175)

Pathways

• Microtubule cytoskeleton organization (Reactome: R-HSA-190236)
• Axon guidance (Reactome: R-HSA-422475)
• MAP2-mediated microtubule stabilization (KEGG: hsa04540)

Protein Summary

MAP2 is a heat-stable, high-molecular-weight microtubule-associated protein predominantly expressed in neuronal dendrites. It promotes microtubule assembly and stability, cross-links microtubules with intermediate filaments, and interacts with actin. The protein contains multiple microtubule-binding repeats and a projection domain that determines spacing between microtubules. Phosphorylation by various kinases (e.g., PKA, CaMKII, CDK5) regulates its binding affinity and function. MAP2 is essential for dendritic arborization and synaptic plasticity.

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Related Products

Product name Cat.No. Species Gene ID
MAP2K3 Knockout HEK293 Cell Line EDJ-KQ681 Human 5606 Details Get a Quote
MAP2K4 Knockout HEK293 Cell Line EDJ-KQ682 Human 6416 Details Get a Quote
MAP2K7 Knockout HEK293 Cell Line EDJ-KQ684 Human 5609 Details Get a Quote
MAP2K5 Knockout HEK293 Cell Line EDJ-KQ1105 Human 5607 Details Get a Quote
MAP2K6 Knockout HEK293 Cell Line EDJ-KQ1353 Human 5608 Details Get a Quote
MAP2 Knockout HEK293 Cell Line EDJ-KQ3258 Human 4133 Details Get a Quote
GIMAP2 Knockout HEK293 Cell Line EDJ-KQ8438 Human 26157 Details Get a Quote
SPMAP2 Knockout HEK293 Cell Line EDJ-KQ11041 Human 51298 Details Get a Quote
SMAP2 Knockout HEK293 Cell Line EDJ-KQ11915 Human 64744 Details Get a Quote
CIMAP2 Knockout HEK293 Cell Line EDJ-KQ14056 Human 163747 Details Get a Quote
SPMAP2L Knockout HEK293 Cell Line EDJ-KQ15719 Human 100506564 Details Get a Quote
MAP2K1 Knockout HEK293 Cell Line EDJ-KQ17832 Human 5604 Details Get a Quote
MAP2K2 Knockout HEK293 Cell Line EDJ-KQ17833 Human 5605 Details Get a Quote
MAP2K4 Knockout HeLa Cell Line EDJ-KQ18121 Human 6416 Details Get a Quote
MAP2K5 Knockout HeLa Cell Line EDJ-KQ18937 Human 5607 Details Get a Quote
Displaying Records 1 To 15 Of 59 Records

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/4133
OMIM https://www.omim.org/entry/157130
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6839
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078018
UniProt https://www.uniprot.org/uniprot/P11137
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=MAP2%5Bgene%5D
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MAP2
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