MAP1LC3C
Microtubule Associated Protein 1 Light Chain 3 Gamma
Gene Information Card
| Symbol | MAP1LC3C |
|---|---|
| Full Name | Microtubule Associated Protein 1 Light Chain 3 Gamma |
| Gene Type | protein-coding |
| Chromosomal Location | 1q43 |
| NCBI Gene ID | 440738 ncbi.nlm.nih.gov/gene/440738 |
| Ensembl ID | ENSG00000197769 |
| UniProt ID | Q9BXW4 |
| OMIM ID | 609604 |
| HGNC ID | 13353 |
| Aliases | LC3C, MAP1ALC3, ATG8F, MAP1LC3A |
Description
MAP1LC3C (Microtubule Associated Protein 1 Light Chain 3 Gamma) is a protein coding gene. It encodes a member of the microtubule-associated protein 1 light chain 3 (LC3) family, which is involved in autophagy. The encoded protein is a ubiquitin-like modifier that is conjugated to autophagosomal membranes and plays a role in autophagosome formation and cargo recognition. Alternative splicing results in multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of autophagy; MAP1LC3C expression altered in tumors | COSMIC, literature |
| Neurodegenerative disorders | Impaired autophagy; altered LC3C levels | Literature, NCBI GeneRIF |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Heart | 1.2 | Low |
| Liver | 0.5 | Low |
| Lung | 1.5 | Low |
| Kidney | 1.0 | Low |
| Testis | 3.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 1.2 | Cervical cancer cell line |
| HEK293 | 0.9 | Embryonic kidney cell line |
| MCF7 | 1.8 | Breast cancer cell line |
| A549 | 1.5 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential impairment of autophagy
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • autophagy (GO:0006914) | • macroautophagy (GO:0016236) |
| • pre-autophagosomal structure membrane (GO:0034045) | • autophagosome membrane (GO:0034053) |
| • protein binding (GO:0005515) | • identical protein binding (GO:0042802) |
Pathways
• Autophagy - Homo sapiens (human) (KEGG: hsa04140)
• Mitophagy - Homo sapiens (human) (Reactome: R-HSA-5205647)
Protein Summary
MAP1LC3C is a 125-amino acid protein (UniProt Q9BXW4) belonging to the ATG8 family. It is processed by ATG4 protease to expose a C-terminal glycine, which is then conjugated to phosphatidylethanolamine on autophagosomal membranes. This lipidated form (LC3C-II) is essential for autophagosome elongation and cargo recruitment. The protein is widely expressed at low levels, with highest expression in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP1LC3C Knockout HEK293 Cell Line | EDJ-KQ1444 | Human | 440738 | Details Get a Quote |
| MAP1LC3C Knockout HeLa Cell Line | EDJ-KQ60405 | Human | 440738 | Details Get a Quote |
| MAP1LC3C Knockout A-549 Cell Line | EDJ-KQ68873 | Human | 440738 | Details Get a Quote |
| MAP1LC3C Knockout HCT 116 Cell Line | EDJ-KQ77235 | Human | 440738 | Details Get a Quote |
