MALL Gene - MAL Like T-Cell Differentiation Protein
Comprehensive gene card for MALL, a member of the MAL family of proteolipids involved in membrane trafficking and T-cell differentiation.
Gene Information Card
| Symbol | MALL |
|---|---|
| Full Name | MAL like T-cell differentiation protein |
| Gene Type | protein-coding |
| Chromosomal Location | 2q13 |
| NCBI Gene ID | 7851 ncbi.nlm.nih.gov/gene/7851 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | Q13021 |
| OMIM ID | 602682 |
| HGNC ID | 6818 |
| Aliases | MAL2, MGC:17330 |
Description
MALL (MAL like T-cell differentiation protein) is a protein-coding gene located on chromosome 2q13. It encodes a member of the MAL family of proteolipids, which are involved in membrane trafficking, particularly in the formation and maintenance of lipid rafts. MALL is expressed in T-cells and other tissues, and its function is linked to T-cell differentiation and signal transduction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Thymus | 8.9 | Medium |
| Bone marrow | 6.3 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.3 | High expression |
| Raji (Burkitt lymphoma) | 8.7 | Medium expression |
| HEK293 (embryonic kidney) | 2.1 | Low expression |
| HeLa (cervical carcinoma) | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) | • intracellular protein transport (GO:0006886) |
| • signal transduction (GO:0007165) | • positive regulation of cell growth (GO:0030307) |
| • T cell activation (GO:0042110) |
Pathways
• No specific pathway annotations in KEGG or Reactome for MALL
Protein Summary
The MALL protein (UniProt Q13021) is a 176-amino acid proteolipid with four transmembrane domains. It localizes to the plasma membrane and is involved in membrane trafficking, particularly in the formation of lipid rafts. It may play a role in T-cell differentiation and signal transduction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MALL Knockout HEK293 Cell Line | EDJ-KQ6136 | Human | 7851 | Details Get a Quote |
| MALL Knockout HeLa Cell Line | EDJ-KQ29917 | Human | 7851 | Details Get a Quote |
| MALL Knockout A-549 Cell Line | EDJ-KQ29915 | Human | 7851 | Details Get a Quote |
| MALL Knockout HCT 116 Cell Line | EDJ-KQ29916 | Human | 7851 | Details Get a Quote |
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