MAGEB16
MAGE Family Member B16
Gene Information Card
| Symbol | MAGEB16 |
|---|---|
| Full Name | MAGE family member B16 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.22 |
| NCBI Gene ID | 139604 ncbi.nlm.nih.gov/gene/139604 |
| Ensembl ID | ENSG00000168916 |
| UniProt ID | Q96M61 |
| OMIM ID | 300761 |
| HGNC ID | 17967 |
| Aliases | MAGE-B16, MAGEB16A, MAGEB16B |
Description
MAGEB16 is a member of the melanoma-associated antigen (MAGE) family, specifically the MAGE-B subfamily. It is located on chromosome Xp11.22 and encodes a protein of unknown function. MAGEB16 is classified as a cancer-testis antigen, with expression predominantly in testis and aberrant activation in various cancers. Its biological role may involve regulation of cell cycle or apoptosis, but detailed mechanisms remain to be elucidated.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Aberrant expression as cancer-testis antigen; potential immunotherapeutic target | Expression observed in tumor samples (COSMIC) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected (GTEx median nTPM < 0.1) |
| Other tissues | 0.0 | No significant expression in normal tissues |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (embryonal carcinoma) | 0.0 | No detectable expression in RNA-seq |
| HeLa | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Potential start-loss, likely loss-of-function |
| c.100C>T (p.Arg34Trp) | missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Protein Summary
The MAGEB16 protein (UniProt Q96M61) is 346 amino acids long and contains a MAGE homology domain. Its exact function is unknown, but it is predicted to localize to the nucleus. No enzymatic activity or binding partners have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEB16 Knockout HEK293 Cell Line | EDJ-KQ9587 | Human | 139604 | Details Get a Quote |
| MAGEB16 Knockout HeLa Cell Line | EDJ-KQ58417 | Human | 139604 | Details Get a Quote |
| MAGEB16 Knockout A-549 Cell Line | EDJ-KQ66906 | Human | 139604 | Details Get a Quote |
| MAGEB16 Knockout HCT 116 Cell Line | EDJ-KQ75309 | Human | 139604 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
