MAGEB10
MAGE Family Member B10
Gene Information Card
| Symbol | MAGEB10 |
|---|---|
| Full Name | MAGE family member B10 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp21.3 |
| NCBI Gene ID | 139422 ncbi.nlm.nih.gov/gene/139422 |
| Ensembl ID | ENSG00000188428 |
| UniProt ID | Q96S60 |
| OMIM ID | 300758 |
| HGNC ID | 6813 |
| Aliases | MAGE-B10, MAGEB10A, MAGEB10B |
Description
MAGEB10 is a member of the melanoma-associated antigen (MAGE) family, specifically the MAGE-B subfamily. It is a cancer-testis antigen (CTA) with predominant expression in testis and aberrant activation in various cancers. The protein contains a conserved MAGE homology domain (MHD) and is involved in protein-protein interactions, potentially modulating cell cycle and apoptosis. MAGEB10 is located on chromosome Xp21.3 and is subject to X-chromosome inactivation escape in some contexts.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | MAGEB10 expression is upregulated in melanoma; may serve as a target for immunotherapy due to its cancer-testis antigen profile. | PubMed: 12529312 |
| Lung Cancer | Aberrant MAGEB10 expression reported in non-small cell lung cancer; potential biomarker. | PubMed: 19680221 |
| Hepatocellular Carcinoma | MAGEB10 mRNA detected in liver cancer tissues; associated with tumor progression. | PubMed: 21804529 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Skin | 0.3 | Not detected |
| Lung | 0.1 | Not detected |
| Liver | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A375 (melanoma) | 8.2 | Moderate expression |
| NCI-H1299 (lung) | 5.1 | Low expression |
| HepG2 (liver) | 0.0 | Not detected |
| MCF7 (breast) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% in COSMIC | Likely loss of start codon; functional impact unknown |
| c.200C>T (p.Pro67Leu) | missense | <0.1% in COSMIC | Substitution in MHD; effect uncertain |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for MAGEB10.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• No specific pathway annotations in Reactome or KEGG for MAGEB10.
Protein Summary
MAGEB10 is a 429-amino acid protein with a molecular weight of approximately 48 kDa. It contains a conserved MAGE homology domain (MHD) spanning residues 120–300. The protein localizes to both cytoplasm and nucleus. As a cancer-testis antigen, its expression is normally restricted to testicular germ cells but is reactivated in various cancers, making it a potential target for cancer immunotherapy. The exact biological function remains under investigation, but it is thought to modulate protein-protein interactions involved in cell cycle regulation and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEB10 Knockout HEK293 Cell Line | EDJ-KQ9545 | Human | 139422 | Details Get a Quote |
| MAGEB10 Knockout HeLa Cell Line | EDJ-KQ58413 | Human | 139422 | Details Get a Quote |
| MAGEB10 Knockout A-549 Cell Line | EDJ-KQ66902 | Human | 139422 | Details Get a Quote |
| MAGEB10 Knockout HCT 116 Cell Line | EDJ-KQ75305 | Human | 139422 | Details Get a Quote |
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