MAGEA2: Melanoma-Associated Antigen 2
Cancer/testis antigen with roles in tumor immune evasion and cell cycle regulation
Gene Information Card
| Symbol | MAGEA2 |
|---|---|
| Full Name | MAGE family member A2 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 4101 ncbi.nlm.nih.gov/gene/4101 |
| Ensembl ID | ENSG00000197121 |
| UniProt ID | P43365 |
| OMIM ID | 300163 |
| HGNC ID | 6759 |
| Aliases | MAGE2, MAGE-2, MAGEA2A, MAGEA2B |
Description
MAGEA2 (MAGE family member A2) is a protein-coding gene located on chromosome Xq28. It belongs to the melanoma-associated antigen (MAGE) family, a group of cancer/testis antigens that are normally expressed only in germ cells but are aberrantly activated in various cancers. The encoded protein is involved in cell cycle regulation, apoptosis inhibition, and immune evasion. MAGEA2 is frequently overexpressed in melanoma, lung cancer, breast cancer, and other malignancies, making it a target for cancer immunotherapy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | Overexpression of MAGEA2 in melanoma cells contributes to immune evasion by downregulating MHC class I expression and inhibiting apoptosis. | NCBI Gene, COSMIC |
| Non-small cell lung cancer | MAGEA2 is frequently expressed in NSCLC and associated with poor prognosis; promotes tumor cell proliferation and resistance to chemotherapy. | NCBI Gene, COSMIC |
| Breast cancer | Aberrant MAGEA2 expression in breast cancer correlates with aggressive subtypes and may serve as a biomarker for immunotherapy. | NCBI Gene, COSMIC |
| Hepatocellular carcinoma | MAGEA2 expression is upregulated in HCC and linked to tumor progression and metastasis. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 0.0 | No detectable expression in normal conditions |
| A549 (lung cancer) | 0.0 | No detectable expression in normal conditions |
| SK-MEL-28 (melanoma) | 0.0 | Expression may be induced in certain sublines |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional impact |
| c.287C>T | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in MAGEA2.
Gain of Function (GOF)
Overexpression in tumors is considered a gain-of-function event, promoting cell survival and immune escape.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Apoptosis modulation
• p53 signaling pathway (via interaction with p53)
• Immune evasion in cancer
Protein Summary
MAGEA2 is a 314-amino acid protein (UniProt P43365) belonging to the MAGE family. It contains a conserved MAGE homology domain (MHD) that mediates protein-protein interactions. The protein is localized in the nucleus and cytoplasm. MAGEA2 can bind to p53 and inhibit its transcriptional activity, thereby suppressing apoptosis. It also interacts with other proteins involved in cell cycle control and immune modulation. Due to its restricted normal expression (testis) and frequent re-expression in cancers, MAGEA2 is considered a cancer/testis antigen and a promising target for cancer vaccines and T-cell-based immunotherapies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEA2B Knockout HEK293 Cell Line | EDJ-KQ13384 | Human | 266740 | Details Get a Quote |
| MAGEA2B Knockout HCT 116 Cell Line | EDJ-KQ44104 | Human | 266740 | Details Get a Quote |
| MAGEA2 Knockout HEK293 Cell Line | EDJ-KQ50426 | Human | 4101 | Details Get a Quote |
| MAGEA2 Knockout HeLa Cell Line | EDJ-KQ53825 | Human | 4101 | Details Get a Quote |
| MAGEA2B Knockout HeLa Cell Line | EDJ-KQ59356 | Human | 266740 | Details Get a Quote |
| MAGEA2 Knockout A-549 Cell Line | EDJ-KQ62308 | Human | 4101 | Details Get a Quote |
| MAGEA2B Knockout A-549 Cell Line | EDJ-KQ67817 | Human | 266740 | Details Get a Quote |
| MAGEA2 Knockout HCT 116 Cell Line | EDJ-KQ70786 | Human | 4101 | Details Get a Quote |
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