MAGEA11: Melanoma-Associated Antigen 11
A cancer-testis antigen with roles in transcriptional regulation and tumorigenesis
Gene Information Card
| Symbol | MAGEA11 |
|---|---|
| Full Name | MAGE family member A11 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 4110 ncbi.nlm.nih.gov/gene/4110 |
| Ensembl ID | ENSG00000185247 |
| UniProt ID | P43364 |
| OMIM ID | 300344 |
| HGNC ID | 6802 |
| Aliases | MAGE-11, MAGE11, CT1.11 |
Description
MAGEA11 is a member of the melanoma-associated antigen (MAGE) gene family, which encodes cancer-testis antigens (CTAs) that are normally expressed in germ cells but aberrantly expressed in various cancers. MAGEA11 functions as a transcriptional co-regulator, interacting with androgen receptor (AR) and other nuclear receptors to modulate gene expression. It is implicated in tumorigenesis, particularly in prostate and breast cancers, and may serve as a target for immunotherapy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | MAGEA11 enhances androgen receptor transcriptional activity, promoting tumor growth | PMID: 19029910 |
| Breast cancer | Overexpression of MAGEA11 correlates with poor prognosis and hormone receptor status | PMID: 23382299 |
| Melanoma | Aberrant expression as a cancer-testis antigen; potential immunotherapeutic target | PMID: 10557338 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Placenta | 0.0 | Not detected |
| Prostate | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 0.0 | Breast cancer cell line; no detectable expression |
| LNCaP | 0.0 | Prostate cancer cell line; no detectable expression |
| SK-MEL-28 | 0.0 | Melanoma cell line; no detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown significance |
| c.100C>T | missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • transcription coregulator activity (GO:0003712) | • nucleus (GO:0005634) |
| • regulation of transcription (GO:0006355) | • nuclear receptor activity (GO:0004879) |
Pathways
• Androgen receptor signaling pathway
• Nuclear receptor transcription pathway
Protein Summary
MAGEA11 is a 429-amino acid protein belonging to the MAGE family. It contains a conserved MAGE homology domain (MHD) and functions as a co-regulator of androgen receptor and other nuclear receptors. The protein is localized to the nucleus and modulates transcription by recruiting coactivators or corepressors. Its expression is typically restricted to testis and placenta but is reactivated in various cancers, contributing to tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEA11 Knockout HEK293 Cell Line | EDJ-KQ4386 | Human | 4110 | Details Get a Quote |
| MAGEA11 Knockout HeLa Cell Line | EDJ-KQ28141 | Human | 4110 | Details Get a Quote |
| MAGEA11 Knockout A-549 Cell Line | EDJ-KQ62316 | Human | 4110 | Details Get a Quote |
| MAGEA11 Knockout HCT 116 Cell Line | EDJ-KQ70794 | Human | 4110 | Details Get a Quote |
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