MAGEA10
Melanoma-Associated Antigen 10: A Cancer/Testis Antigen with Restricted Expression
Gene Information Card
| Symbol | MAGEA10 |
|---|---|
| Full Name | MAGE family member A10 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 4109 ncbi.nlm.nih.gov/gene/4109 |
| Ensembl ID | ENSG00000124212 |
| UniProt ID | P43363 |
| OMIM ID | 300342 |
| HGNC ID | 6800 |
| Aliases | MAGE-10, MAGE10, CT1.10 |
Description
MAGEA10 (MAGE family member A10) is a protein-coding gene belonging to the melanoma-associated antigen (MAGE) family. It is a cancer/testis antigen (CTA) with expression normally restricted to testis germ cells but frequently re-expressed in various cancers, including melanoma, lung, and bladder carcinomas. The encoded protein is involved in protein ubiquitination and may modulate cell cycle regulation and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | Re-expression of MAGEA10 in melanoma cells contributes to immune evasion and tumor progression. | NCBI Gene, COSMIC |
| Non-small cell lung cancer | MAGEA10 is aberrantly expressed and associated with poor prognosis. | NCBI Gene, COSMIC |
| Bladder carcinoma | Overexpression observed in bladder tumors; potential target for immunotherapy. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected (nTPM data not available for MAGEA10 in GTEx) |
| Skin | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SK-MEL-28 | 0.0 | Melanoma cell line; MAGEA10 expression may be induced by demethylation |
| A549 | 0.0 | Lung carcinoma cell line; low baseline expression |
| T24 | 0.0 | Bladder carcinoma cell line; expression reported in some studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional effect |
| c.100C>T | missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in MAGEA10.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • ubiquitin-dependent protein catabolic process (GO:0006511) |
Pathways
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)
• p53 signaling pathway (indirect modulation via MAGE family members)
Protein Summary
MAGEA10 encodes a 369-amino acid protein belonging to the MAGE family. It contains a conserved MAGE homology domain (MHD) and is localized to the cytoplasm and nucleus. The protein interacts with E3 ubiquitin ligases, potentially regulating protein degradation and influencing cell cycle and apoptosis. As a cancer/testis antigen, it is a target for cancer immunotherapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEA10 Knockout HEK293 Cell Line | EDJ-KQ5165 | Human | 4109 | Details Get a Quote |
| MAGEA10 Knockout HeLa Cell Line | EDJ-KQ53832 | Human | 4109 | Details Get a Quote |
| MAGEA10 Knockout A-549 Cell Line | EDJ-KQ62315 | Human | 4109 | Details Get a Quote |
| MAGEA10 Knockout HCT 116 Cell Line | EDJ-KQ70793 | Human | 4109 | Details Get a Quote |
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