MAFG Gene - MAF BZIP Transcription Factor G
A key regulator of gene expression in cellular stress responses and differentiation.
Gene Information Card
| Symbol | MAFG |
|---|---|
| Full Name | MAF bZIP transcription factor G |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 4097 ncbi.nlm.nih.gov/gene/4097 |
| Ensembl ID | ENSG00000197063 |
| UniProt ID | O15525 |
| OMIM ID | 602020 |
| HGNC ID | 6781 |
| Aliases | hMAF, MGC130013, MGC130014 |
Description
MAFG (MAF bZIP transcription factor G) is a member of the MAF family of basic leucine zipper (bZIP) transcription factors. It forms homodimers or heterodimers with other bZIP proteins, such as NFE2, to regulate gene expression. MAFG is involved in cellular stress responses, differentiation, and hematopoiesis. It plays a role in the antioxidant response by binding to antioxidant response elements (AREs) in the promoters of target genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MAFG overexpression or mutation may alter transcriptional programs affecting cell proliferation and survival. | COSMIC; PMID: 25691885 |
| Hereditary elliptocytosis | Mutations in MAFG have been associated with red blood cell membrane disorders. | OMIM #602020; PMID: 10447258 |
| Oxidative stress-related disorders | MAFG regulates antioxidant genes via ARE; dysregulation contributes to disease. | NCBI Gene; PMID: 12529312 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Bone marrow | 8.3 | Medium |
| Spleen | 7.1 | Low |
| Lung | 5.9 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.2 | High expression in leukemia cell line |
| HepG2 | 10.1 | Moderate expression in liver cancer cell line |
| A549 | 6.3 | Low expression in lung cancer cell line |
| HEK293 | 4.5 | Low expression in embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.197C>T (p.Pro66Leu) | Missense | <0.01% | May alter DNA-binding affinity |
| c.334G>A (p.Gly112Arg) | Missense | <0.01% | Reported in COSMIC; potential functional impact |
| c.458_459insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to result in loss of function.
Gain of Function (GOF)
Not well characterized; some missense variants may enhance transcriptional activity.
Dominant Negative (DN)
Heterodimerization with other bZIP factors could be disrupted by certain mutations.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Antioxidant response (ARE) pathway
• NFE2/MAF signaling in erythropoiesis
• Cellular stress response
Protein Summary
MAFG is a 162-amino acid protein containing a bZIP domain that mediates dimerization and DNA binding. It is predominantly nuclear and functions as a transcriptional activator or repressor depending on its dimerization partner. MAFG is critical for the expression of phase II detoxifying enzymes and antioxidant proteins, and it plays a role in erythroid differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAFG Knockout HEK293 Cell Line | EDJ-KQ50425 | Human | 4097 | Details Get a Quote |
| MAFG Knockout HeLa Cell Line | EDJ-KQ53823 | Human | 4097 | Details Get a Quote |
| MAFG Knockout A-549 Cell Line | EDJ-KQ62305 | Human | 4097 | Details Get a Quote |
| MAFG Knockout HCT 116 Cell Line | EDJ-KQ70783 | Human | 4097 | Details Get a Quote |
