LZTS2 Leucine Zipper Tumor Suppressor 2
A tumor suppressor gene encoding a leucine zipper protein involved in cell cycle regulation and cancer suppression.
Gene Information Card
| Symbol | LZTS2 |
|---|---|
| Full Name | Leucine Zipper Tumor Suppressor 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q24.31 |
| NCBI Gene ID | 84443 ncbi.nlm.nih.gov/gene/84443 |
| Ensembl ID | ENSG00000138160 |
| UniProt ID | Q9BQE3 |
| OMIM ID | 609543 |
| HGNC ID | 29488 |
| Aliases | LZTS2, LAPSER1, PRO1581 |
Description
LZTS2 (leucine zipper tumor suppressor 2) is a protein-coding gene located on chromosome 10q24.31. It encodes a leucine zipper-containing protein that functions as a tumor suppressor by regulating cell cycle progression, particularly through interaction with cyclin-dependent kinases and the anaphase-promoting complex. LZTS2 is involved in mitotic spindle assembly and cytokinesis. Loss of LZTS2 expression has been implicated in various cancers, including prostate, breast, and lung cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Loss of LZTS2 expression leads to deregulated cell cycle and increased proliferation | PMID: 19029980 |
| Breast cancer | Reduced LZTS2 mRNA levels correlate with poor prognosis | PMID: 21573172 |
| Lung cancer | Epigenetic silencing of LZTS2 via promoter methylation | PMID: 23361059 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 8.3 | Low |
| Breast | 6.1 | Low |
| Lung | 5.4 | Low |
| Brain | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 9.8 | Cervical cancer cell line |
| MCF7 | 7.2 | Breast cancer cell line |
| A549 | 6.5 | Lung cancer cell line |
| PC3 | 4.1 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163*) | Nonsense | <1% | Loss of function |
| c.632_633del (p.Glu211fs) | Frameshift | <1% | Loss of function |
| c.100G>A (p.Gly34Arg) | Missense | <1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated protein and loss of tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cell cycle | • mitotic spindle assembly |
| • cytokinesis | • protein binding |
| • leucine zipper domain |
Pathways
• Cell cycle
• p53 signaling pathway
• APC/C-mediated degradation
Protein Summary
The LZTS2 protein (UniProt Q9BQE3) is a 421-amino acid leucine zipper-containing protein. It localizes to the centrosome and spindle poles during mitosis, where it regulates microtubule dynamics and cytokinesis. LZTS2 interacts with cyclin B1 and the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit. Its tumor suppressor function is mediated through cell cycle arrest and inhibition of proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LZTS2 Knockout HEK293 Cell Line | EDJ-KQ10087 | Human | 84445 | Details Get a Quote |
| LZTS2 Knockout A-549 Cell Line | EDJ-KQ37157 | Human | 84445 | Details Get a Quote |
| LZTS2 Knockout HCT 116 Cell Line | EDJ-KQ37158 | Human | 84445 | Details Get a Quote |
| LZTS2 Knockout HeLa Cell Line | EDJ-KQ37159 | Human | 84445 | Details Get a Quote |
