LYZL6
Lysozyme-like 6
Gene Information Card
| Symbol | LYZL6 |
|---|---|
| Full Name | lysozyme-like 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 57151 ncbi.nlm.nih.gov/gene/57151 |
| Ensembl ID | ENSG00000108797 |
| UniProt ID | Q8N4Q1 |
| OMIM ID | 616747 |
| HGNC ID | 29363 |
| Aliases | LYZL6, LYC2, LYZL6A |
Description
LYZL6 (lysozyme-like 6) is a protein-coding gene located on chromosome 17q11.2. It encodes a member of the lysozyme-like family, which are antimicrobial proteins with potential roles in host defense. The protein is predicted to have lysozyme activity, though its specific biological functions and substrates remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 5.2 | Low |
| Lung | 3.1 | Low |
| Kidney | 2.8 | Low |
| Liver | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| HeLa | 0.3 | Low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity (GO:0003796) | • defense response to Gram-positive bacterium (GO:0050830) |
| • extracellular region (GO:0005576) |
Pathways
• No curated pathways
Protein Summary
LYZL6 is a 148-amino acid protein belonging to the lysozyme-like family. It contains a conserved lysozyme domain and is predicted to function as an antimicrobial enzyme, cleaving peptidoglycan in bacterial cell walls. Expression is highest in testis, suggesting a possible role in reproductive immunity. The protein is secreted and localizes to the extracellular space.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYZL6 Knockout HEK293 Cell Line | EDJ-KQ14168 | Human | 57151 | Details Get a Quote |
| LYZL6 Knockout HeLa Cell Line | EDJ-KQ56815 | Human | 57151 | Details Get a Quote |
| LYZL6 Knockout A-549 Cell Line | EDJ-KQ65323 | Human | 57151 | Details Get a Quote |
| LYZL6 Knockout HCT 116 Cell Line | EDJ-KQ73759 | Human | 57151 | Details Get a Quote |
