LYZL4
Lysozyme Like 4
Gene Information Card
| Symbol | LYZL4 |
|---|---|
| Full Name | Lysozyme Like 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 84550 ncbi.nlm.nih.gov/gene/84550 |
| Ensembl ID | ENSG00000163823 |
| UniProt ID | Q96BZ9 |
| OMIM ID | 617392 |
| HGNC ID | 25090 |
| Aliases | LYZ4, LYC4, LYZL4 |
Description
LYZL4 (Lysozyme Like 4) is a protein-coding gene located on chromosome 3p21.31. It encodes a member of the lysozyme family, which are antimicrobial enzymes that hydrolyze bacterial cell wall peptidoglycans. LYZL4 is expressed in various tissues and may play a role in host defense and immune response. The gene is also implicated in certain cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression; potential tumor suppressor role | COSMIC, NCBI |
| Breast cancer | Differential methylation and expression changes | COSMIC, NCBI |
| Inflammatory bowel disease | Possible involvement in mucosal immunity | NCBI, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 8.3 | Low |
| Lung | 6.1 | Low |
| Breast | 4.7 | Low |
| Colon | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate) | 9.8 | Prostate cancer cell line |
| MCF-7 (breast) | 5.4 | Breast cancer cell line |
| A549 (lung) | 4.1 | Lung cancer cell line |
| HT-29 (colon) | 3.0 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.217G>A (p.Gly73Arg) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.334C>T (p.Arg112Trp) | Missense | 0.005% (gnomAD) | Potential loss of function |
| c.451_453del (p.Lys151del) | In-frame deletion | Rare | Unknown |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg112Trp) may reduce lysozyme activity.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity | • peptidoglycan catabolic process |
| • defense response to bacterium | • extracellular region |
Pathways
• Lysozyme-mediated antibacterial response
• Innate immune system
Protein Summary
LYZL4 encodes a lysozyme-like protein of approximately 148 amino acids. It contains a conserved lysozyme domain and is predicted to have bacteriolytic activity. The protein is secreted and may contribute to mucosal immunity. Structural studies suggest a typical lysozyme fold with catalytic residues (Glu53, Asp72) essential for activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYZL4 Knockout HEK293 Cell Line | EDJ-KQ9265 | Human | 131375 | Details Get a Quote |
| LYZL4 Knockout HeLa Cell Line | EDJ-KQ58294 | Human | 131375 | Details Get a Quote |
| LYZL4 Knockout A-549 Cell Line | EDJ-KQ66782 | Human | 131375 | Details Get a Quote |
| LYZL4 Knockout HCT 116 Cell Line | EDJ-KQ75185 | Human | 131375 | Details Get a Quote |
