LYZL1
Lysozyme-like 1
Gene Information Card
| Symbol | LYZL1 |
|---|---|
| Full Name | lysozyme-like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 10p12.1 |
| NCBI Gene ID | 84569 ncbi.nlm.nih.gov/gene/84569 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | Q8N4E1 |
| OMIM ID | 616830 |
| HGNC ID | 25038 |
| Aliases | LYZL, LYZL1 |
Description
LYZL1 encodes a member of the lysozyme-like protein family. The protein has bacteriolytic activity and is involved in host defense. It is expressed in various tissues, including testis and epididymis, and may play a role in male fertility.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Potential role in sperm maturation and antimicrobial defense in the male reproductive tract | Limited; expression studies suggest involvement |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Epididymis | 8.3 | Low |
| Lung | 1.2 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.8 | Low expression |
| A549 | 1.1 | Low expression |
| HEK293 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity | • defense response to bacterium |
| • extracellular region |
Pathways
• No specific pathways curated
Protein Summary
LYZL1 is a 148-amino-acid protein with lysozyme-like activity, capable of hydrolyzing bacterial cell wall peptidoglycans. It is secreted and may contribute to antimicrobial defense in reproductive tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYZL1 Knockout HEK293 Cell Line | EDJ-KQ51853 | Human | 84569 | Details Get a Quote |
| LYZL1 Knockout HeLa Cell Line | EDJ-KQ57614 | Human | 84569 | Details Get a Quote |
| LYZL1 Knockout A-549 Cell Line | EDJ-KQ66112 | Human | 84569 | Details Get a Quote |
| LYZL1 Knockout HCT 116 Cell Line | EDJ-KQ74534 | Human | 84569 | Details Get a Quote |
