LYVE1: Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Key marker of lymphatic endothelium and hyaluronan metabolism
Gene Information Card
| Symbol | LYVE1 |
|---|---|
| Full Name | Lymphatic Vessel Endothelial Hyaluronan Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 10894 ncbi.nlm.nih.gov/gene/10894 |
| Ensembl ID | ENSG00000133800 |
| UniProt ID | Q9Y5Y7 |
| OMIM ID | 605702 |
| HGNC ID | 14687 |
| Aliases | CRSBP-1, HAR, LYVE-1, XLKD1 |
Description
LYVE1 encodes a type I integral membrane glycoprotein that functions as a receptor for hyaluronan (HA), a major component of the extracellular matrix. It is specifically expressed on lymphatic endothelial cells and is involved in hyaluronan transport and metabolism, as well as in lymphatic cell migration and tumor metastasis. LYVE1 is widely used as a marker for lymphatic vessels in research and pathology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lymphedema | Potential role in lymphatic dysfunction; LYVE1 expression altered in lymphatic malformations | PMID: 20041168 |
| Cancer metastasis | LYVE1-mediated hyaluronan binding facilitates tumor cell entry into lymphatic vessels | PMID: 11514563 |
| Inflammatory bowel disease | Increased LYVE1+ lymphatic vessels observed in inflamed mucosa | PMID: 20837698 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 10.2 | High |
| Lung | 8.1 | Medium |
| Heart | 6.3 | Medium |
| Liver | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (umbilical vein endothelial) | 0.2 | Not expressed |
| Lymphatic endothelial cells (LEC) | 45.0 | High expression |
| THP-1 (monocyte) | 0.1 | Not expressed |
| A549 (lung carcinoma) | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect |
| c.1021G>A (p.Gly341Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in LYVE1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in LYVE1.
Dominant Negative (DN)
No dominant-negative mutations reported in LYVE1.
View complete mutation data：
Gene Ontology (GO)
| • hyaluronic acid binding (GO:0005540) | • integral component of membrane (GO:0016021) |
| • positive regulation of cell growth (GO:0030307) | • collagen catabolic process (GO:0030574) |
| • positive regulation of GTPase activity (GO:0043547) |
Pathways
• Hyaluronan metabolism and transport
• Lymphatic vessel development
Protein Summary
LYVE1 is a 322-amino acid transmembrane protein with a single extracellular domain that binds hyaluronan. It is highly glycosylated and forms disulfide-linked homodimers on the cell surface. The protein is specifically expressed on lymphatic endothelial cells and is involved in the internalization and degradation of hyaluronan, as well as in mediating cell adhesion and migration. LYVE1 is a key marker for lymphatic vessels and is used in studies of lymphangiogenesis, tumor metastasis, and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYVE1 Knockout HEK293 Cell Line | EDJ-KQ3152 | Human | 10894 | Details Get a Quote |
| LYVE1 Knockout HeLa Cell Line | EDJ-KQ55519 | Human | 10894 | Details Get a Quote |
| LYVE1 Knockout A-549 Cell Line | EDJ-KQ64009 | Human | 10894 | Details Get a Quote |
| LYVE1 Knockout HCT 116 Cell Line | EDJ-KQ72461 | Human | 10894 | Details Get a Quote |
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