LYSMD3
LysM Domain Containing 3
Gene Information Card
| Symbol | LYSMD3 |
|---|---|
| Full Name | LysM Domain Containing 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q13.3 |
| NCBI Gene ID | 26068 ncbi.nlm.nih.gov/gene/26068 |
| Ensembl ID | ENSG00000164330 |
| UniProt ID | Q7Z3D4 |
| OMIM ID | 617755 |
| HGNC ID | 28423 |
| Aliases | FLJ22662, MGC13170 |
Description
LYSMD3 (LysM Domain Containing 3) is a protein-coding gene located on chromosome 5q13.3. The encoded protein contains a LysM domain, which is involved in peptidoglycan binding and may play a role in innate immunity or cell wall metabolism. LYSMD3 is expressed in various tissues and has been implicated in certain cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Altered expression; potential role in tumorigenesis | COSMIC, NCBI Gene |
| Developmental disorders | Possible involvement in cell signaling | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Liver | 8.1 | Low |
| Brain | 6.3 | Low |
| Heart | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 15.3 | High expression |
| HEK293 (embryonic kidney) | 11.0 | Moderate expression |
| HepG2 (liver cancer) | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown significance |
| c.456G>A | Synonymous | <0.1% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • membrane (GO:0016020) |
| • extracellular region (GO:0005576) |
Pathways
• No curated pathways available
Protein Summary
The LYSMD3 protein (UniProt Q7Z3D4) contains a LysM domain, which is typically involved in binding to peptidoglycan or other carbohydrate structures. Its exact function is not fully characterized, but it may participate in cell wall metabolism or immune recognition. The protein is predicted to be secreted or membrane-associated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYSMD3 Knockout HEK293 Cell Line | EDJ-KQ7544 | Human | 116068 | Details Get a Quote |
| LYSMD3 Knockout A-549 Cell Line | EDJ-KQ32840 | Human | 116068 | Details Get a Quote |
| LYSMD3 Knockout HCT 116 Cell Line | EDJ-KQ32841 | Human | 116068 | Details Get a Quote |
| LYSMD3 Knockout HeLa Cell Line | EDJ-KQ32842 | Human | 116068 | Details Get a Quote |
