LYNX1
Ly6/Neurotoxin 1
Gene Information Card
| Symbol | LYNX1 |
|---|---|
| Full Name | Ly6/Neurotoxin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.3 |
| NCBI Gene ID | 66004 ncbi.nlm.nih.gov/gene/66004 |
| Ensembl ID | ENSG00000180155 |
| UniProt ID | Q9NZS3 |
| OMIM ID | 606110 |
| HGNC ID | 18385 |
| Aliases | SLURP1, LYNX, LYNX1A, LYNX1B |
Description
LYNX1 encodes a member of the Ly6/neurotoxin family of proteins. The encoded protein is a secreted or membrane-bound modulator of nicotinic acetylcholine receptors (nAChRs), particularly in the nervous system. It acts as an allosteric modulator, enhancing or inhibiting receptor function depending on the subunit composition. LYNX1 is involved in synaptic plasticity, cognitive function, and has been implicated in neurological disorders and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | LYNX1 modulates α7 nAChR; altered expression may contribute to cholinergic dysfunction | ClinVar, PMID: 22968133 |
| Alzheimer's disease | Reduced LYNX1 expression linked to cognitive decline and amyloid-beta pathology | NCBI Gene, PMID: 25319628 |
| Lung cancer | LYNX1 overexpression in non-small cell lung cancer; modulates nAChR-mediated cell proliferation | COSMIC, PMID: 21750110 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Testis | 6.1 | Low |
| Spinal cord | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 10.1 | Neuroblastoma cell line |
| A549 | 7.4 | Lung carcinoma cell line |
| HEK293 | 2.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.67C>T | Missense | <0.01% | p.Arg23Cys; altered protein structure |
Mutation functional classification
Loss of Function (LOF)
Missense variants affecting start codon or conserved residues may reduce protein expression or nAChR modulation.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nicotinic acetylcholine receptor signaling pathway
• Synaptic modulation
Protein Summary
LYNX1 is a 101-amino acid protein containing a signal peptide and a Ly6/uPAR domain with 10 conserved cysteine residues forming 5 disulfide bonds. It is anchored to the plasma membrane via a GPI-link or secreted. The protein binds to nicotinic acetylcholine receptors (α7, α4β2) and modulates their desensitization and agonist sensitivity. In the brain, LYNX1 regulates cholinergic signaling, synaptic plasticity, and cognitive processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYNX1 Knockout HEK293 Cell Line | EDJ-KQ51646 | Human | 66004 | Details Get a Quote |
| LYNX1 Knockout HeLa Cell Line | EDJ-KQ57117 | Human | 66004 | Details Get a Quote |
| LYNX1 Knockout A-549 Cell Line | EDJ-KQ65631 | Human | 66004 | Details Get a Quote |
| LYNX1 Knockout HCT 116 Cell Line | EDJ-KQ74054 | Human | 66004 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
