LYG2: Lysozyme G2
A member of the lysozyme-like protein family with potential roles in host defense and immune modulation.
Gene Information Card
| Symbol | LYG2 |
|---|---|
| Full Name | Lysozyme G2 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 254773 ncbi.nlm.nih.gov/gene/254773 |
| Ensembl ID | ENSG00000188263 |
| UniProt ID | Q8N4E1 |
| OMIM ID | 617523 |
| HGNC ID | 28044 |
| Aliases | LYG2, Lysozyme G2 |
Description
LYG2 encodes lysozyme G2, a member of the lysozyme-like protein family. Lysozymes are antimicrobial enzymes that cleave peptidoglycan in bacterial cell walls. LYG2 is expressed in various tissues and may play a role in innate immunity and host defense. Its specific functions and disease associations are under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.3 | Low |
| Spleen | 0.2 | Low |
| Bone marrow | 0.1 | Low |
| Testis | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data | No curated cell line expression data in available databases |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | No COSMIC or ClinVar entries for LYG2 |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity (GO:0003796) | • defense response to Gram-positive bacterium (GO:0050830) |
Pathways
• ['No curated pathways']
Protein Summary
Lysozyme G2 is a secreted protein with predicted lysozyme activity, capable of hydrolyzing bacterial peptidoglycan. Its structure includes a conserved lysozyme domain. The protein may contribute to antimicrobial defense in mucosal surfaces and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYG2 Knockout HEK293 Cell Line | EDJ-KQ11773 | Human | 254773 | Details Get a Quote |
| LYG2 Knockout HeLa Cell Line | EDJ-KQ59258 | Human | 254773 | Details Get a Quote |
| LYG2 Knockout A-549 Cell Line | EDJ-KQ67725 | Human | 254773 | Details Get a Quote |
| LYG2 Knockout HCT 116 Cell Line | EDJ-KQ76110 | Human | 254773 | Details Get a Quote |
