LYG1: Lysozyme G1
A member of the lysozyme G family with potential antimicrobial and immune-modulatory roles.
Gene Information Card
| Symbol | LYG1 |
|---|---|
| Full Name | Lysozyme G1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 64593 ncbi.nlm.nih.gov/gene/64593 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9BVP2 |
| OMIM ID | 617394 |
| HGNC ID | 26239 |
| Aliases | LYG, LYG-1, lysozyme G-like 1 |
Description
LYG1 encodes lysozyme G1, a member of the lysozyme G family. Lysozymes are antimicrobial enzymes that cleave peptidoglycan in bacterial cell walls. LYG1 is expressed in various tissues and may play a role in innate immunity and host defense. Its precise physiological functions and disease associations are under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No curated evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 0.8 | Low |
| Lung | 0.5 | Low |
| Spleen | 0.3 | Low |
| Testis | 0.2 | Low |
| Kidney | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 0.6 | Leukemia cell line |
| A549 | 0.4 | Lung carcinoma cell line |
| HeLa | 0.3 | Cervical carcinoma cell line |
| HepG2 | 0.2 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity (GO:0003796) | • cell wall macromolecule catabolic process (GO:0016998) |
| • defense response to bacterium (GO:0042742) | • extracellular region (GO:0005576) |
Pathways
• No specific pathway annotations in curated databases.
Protein Summary
Lysozyme G1 (UniProt Q9BVP2) is a 244-amino acid protein with a predicted lysozyme fold. It contains a conserved catalytic glutamic acid residue essential for peptidoglycan hydrolysis. The protein is secreted and may function in mucosal and systemic antimicrobial defense. Structural and functional studies are limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYG1 Knockout HEK293 Cell Line | EDJ-KQ9218 | Human | 129530 | Details Get a Quote |
| LYG1 Knockout A-549 Cell Line | EDJ-KQ35783 | Human | 129530 | Details Get a Quote |
| LYG1 Knockout HCT 116 Cell Line | EDJ-KQ35784 | Human | 129530 | Details Get a Quote |
| LYG1 Knockout HeLa Cell Line | EDJ-KQ58263 | Human | 129530 | Details Get a Quote |
