LYAR Gene (Ly1 Antibody Reactive)
Nucleolar protein involved in ribosome biogenesis, cell growth, and tumor suppression
Gene Information Card
| Symbol | LYAR |
|---|---|
| Full Name | Ly1 Antibody Reactive |
| Gene Type | Protein coding |
| Chromosomal Location | 4p16.3 |
| NCBI Gene ID | 55646 ncbi.nlm.nih.gov/gene/55646 |
| Ensembl ID | ENSG00000138674 |
| UniProt ID | Q9NX58 |
| OMIM ID | 617753 |
| HGNC ID | 29580 |
| Aliases | ZFP2, ZNF2, Ly-1 antibody reactive |
Description
The LYAR gene encodes a nucleolar zinc finger protein that plays a role in ribosome biogenesis, cell growth regulation, and tumor suppression. It is involved in pre-rRNA processing and can act as a transcriptional regulator. LYAR is also implicated in cellular stress responses and has been associated with various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | LYAR overexpression may promote leukemogenesis by enhancing ribosome biogenesis and cell proliferation. | PMID: 25605248 |
| Colorectal Cancer | LYAR is upregulated and associated with poor prognosis; may drive tumor growth via ribosomal RNA synthesis. | PMID: 29367608 |
| Hepatocellular Carcinoma | LYAR expression is elevated and correlates with tumor progression and metastasis. | PMID: 31073040 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone Marrow | 8.2 | Low |
| Lymph Node | 7.1 | Low |
| Spleen | 6.8 | Low |
| Brain | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 15.3 | Leukemia cell line |
| HeLa | 12.1 | Cervical cancer cell line |
| HepG2 | 10.5 | Hepatocellular carcinoma cell line |
| A549 | 9.8 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
Not documented in curated databases.
Dominant Negative (DN)
Not documented in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • nucleolus (GO:0005730) | • nucleic acid binding (GO:0003676) |
| • zinc ion binding (GO:0008270) | • rRNA processing (GO:0006364) |
| • ribosome biogenesis (GO:0042254) | • nucleus (GO:0005634) |
Pathways
• Ribosome biogenesis in eukaryotes (Reactome: R-HSA-6791226)
• rRNA processing in the nucleus and cytosol (Reactome: R-HSA-8868773)
Protein Summary
The LYAR protein is a nucleolar zinc finger protein that binds nucleic acids and participates in pre-rRNA processing. It is essential for ribosome biogenesis and cell proliferation. LYAR also functions as a transcriptional regulator and is implicated in tumor suppression, though its overexpression in certain cancers suggests a context-dependent role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYAR Knockout HEK293 Cell Line | EDJ-KQ13378 | Human | 55646 | Details Get a Quote |
| LYAR Knockout A-549 Cell Line | EDJ-KQ44090 | Human | 55646 | Details Get a Quote |
| LYAR Knockout HCT 116 Cell Line | EDJ-KQ44092 | Human | 55646 | Details Get a Quote |
| LYAR Knockout HeLa Cell Line | EDJ-KQ44093 | Human | 55646 | Details Get a Quote |
