LY6D: Lymphocyte Antigen 6 Family Member D
A GPI-anchored cell surface protein involved in B cell development and cancer
Gene Information Card
| Symbol | LY6D |
|---|---|
| Full Name | Lymphocyte Antigen 6 Family Member D |
| Gene Type | protein-coding |
| Chromosomal Location | 8q24.3 |
| NCBI Gene ID | 8581 ncbi.nlm.nih.gov/gene/8581 |
| Ensembl ID | ENSG00000167657 |
| UniProt ID | Q9H7G8 |
| OMIM ID | 610086 |
| HGNC ID | 6729 |
| Aliases | LY6D, E48, Ly-6D, MGC2284 |
Description
LY6D encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the Ly-6/uPAR family. It is expressed on early B cells and certain epithelial cells, playing a role in B cell development and differentiation. LY6D is also implicated in various cancers, including head and neck squamous cell carcinoma and acute lymphoblastic leukemia, where it serves as a diagnostic and prognostic marker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Lymphoblastic Leukemia (B-ALL) | LY6D is highly expressed on B-cell precursors; used as a flow cytometry marker for minimal residual disease detection. | ClinVar, PubMed |
| Head and Neck Squamous Cell Carcinoma (HNSCC) | Overexpression of LY6D promotes tumor cell migration and invasion via GPI-anchor signaling. | COSMIC, PubMed |
| Breast Cancer | LY6D expression correlates with poor prognosis and may regulate epithelial-mesenchymal transition. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Lymph Node | 8.3 | Medium |
| Spleen | 6.1 | Low |
| Tonsil | 5.4 | Low |
| Skin | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| REH (B-ALL) | 45.2 | High expression; used as positive control |
| MCF7 (Breast) | 3.8 | Low expression |
| HEK293 | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; effect unknown |
| c.200C>T (p.Thr67Ile) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cell surface | • GPI-anchor |
| • signal transduction | • B cell differentiation |
| • positive regulation of cell migration |
Pathways
• GPI-anchor biosynthesis
• B cell receptor signaling
Protein Summary
LY6D is a 131-amino acid GPI-anchored protein with a single Ly-6/uPAR domain. It is attached to the plasma membrane via a glycosylphosphatidylinositol anchor and is involved in cell adhesion and signaling. The protein is a marker for early B cell development and is aberrantly expressed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LY6D Knockout HEK293 Cell Line | EDJ-KQ6294 | Human | 8581 | Details Get a Quote |
| LY6D Knockout HeLa Cell Line | EDJ-KQ30198 | Human | 8581 | Details Get a Quote |
| LY6D Knockout A-549 Cell Line | EDJ-KQ63433 | Human | 8581 | Details Get a Quote |
| LY6D Knockout HCT 116 Cell Line | EDJ-KQ71899 | Human | 8581 | Details Get a Quote |
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