LXN (Latexin)
A carboxypeptidase inhibitor with roles in inflammation, cancer, and stem cell regulation
Gene Information Card
| Symbol | LXN |
|---|---|
| Full Name | Latexin |
| Gene Type | protein-coding |
| Chromosomal Location | 3q25.32 |
| NCBI Gene ID | 56925 ncbi.nlm.nih.gov/gene/56925 |
| Ensembl ID | ENSG00000163634 |
| UniProt ID | Q9BS40 |
| OMIM ID | 609173 |
| HGNC ID | 13347 |
| Aliases | ECI, TCI, MGC117188, MGC138290 |
Description
LXN (latexin) encodes a protein that functions as a carboxypeptidase A inhibitor. It is involved in inflammation, cancer progression, and stem cell regulation. Latexin is expressed in various tissues and is downregulated in several cancers, suggesting a tumor suppressor role.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Downregulation of LXN may promote tumor growth and metastasis | PMID: 20628086 |
| Colorectal cancer | Reduced LXN expression correlates with poor prognosis | PMID: 23593055 |
| Gastric cancer | LXN methylation leads to silencing and tumor progression | PMID: 21217848 |
| Inflammatory diseases | LXN inhibits carboxypeptidase A, modulating inflammation | PMID: 15616553 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 15.2 | Medium |
| Lung | 9.7 | Low |
| Pancreas | 18.4 | Medium |
| Prostate | 22.1 | High |
| Colon | 14.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.5 | Cervical cancer cell line |
| HepG2 | 8.2 | Liver cancer cell line |
| A549 | 7.9 | Lung cancer cell line |
| MCF7 | 12.1 | Breast cancer cell line |
| PC3 | 5.3 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
| c.200G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • endopeptidase inhibitor activity (GO:0004866) | • cytoplasm (GO:0005737) |
| • extracellular space (GO:0005615) | • negative regulation of endopeptidase activity (GO:0010951) |
Pathways
• Carboxypeptidase A inhibition
• Inflammatory response regulation
Protein Summary
Latexin is a 222-amino acid protein that inhibits carboxypeptidase A, a metalloprotease involved in peptide processing. It is secreted and can modulate inflammation and cell proliferation. The protein is downregulated in several cancers, suggesting a tumor suppressor function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLXNB1 Knockout HEK293 Cell Line | EDJ-KQ1466 | Human | 5364 | Details Get a Quote |
| PLXNA1 Knockout HEK293 Cell Line | EDJ-KQ5485 | Human | 5361 | Details Get a Quote |
| PLXNA2 Knockout HEK293 Cell Line | EDJ-KQ5486 | Human | 5362 | Details Get a Quote |
| PLXNA3 Knockout HEK293 Cell Line | EDJ-KQ5487 | Human | 55558 | Details Get a Quote |
| PLXNB3 Knockout HEK293 Cell Line | EDJ-KQ5489 | Human | 5365 | Details Get a Quote |
| PLXNC1 Knockout HEK293 Cell Line | EDJ-KQ6922 | Human | 10154 | Details Get a Quote |
| PLXND1 Knockout HEK293 Cell Line | EDJ-KQ7843 | Human | 23129 | Details Get a Quote |
| PLXNB2 Knockout HEK293 Cell Line | EDJ-KQ8112 | Human | 23654 | Details Get a Quote |
| PLXNA4 Knockout HEK293 Cell Line | EDJ-KQ10750 | Human | 91584 | Details Get a Quote |
| CLXN Knockout HEK293 Cell Line | EDJ-KQ12955 | Human | 79645 | Details Get a Quote |
| LXN Knockout HEK293 Cell Line | EDJ-KQ14158 | Human | 56925 | Details Get a Quote |
| PLXND1 Knockout HCT 116 Cell Line | EDJ-KQ32069 | Human | 23129 | Details Get a Quote |
| PLXNB2 Knockout A-549 Cell Line | EDJ-KQ33989 | Human | 23654 | Details Get a Quote |
| PLXNB2 Knockout HCT 116 Cell Line | EDJ-KQ33990 | Human | 23654 | Details Get a Quote |
| PLXNB2 Knockout HeLa Cell Line | EDJ-KQ33991 | Human | 23654 | Details Get a Quote |
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