LTB4R2 (Leukotriene B4 Receptor 2)
A G protein-coupled receptor for leukotriene B4 involved in inflammation and immune response.
Gene Information Card
| Symbol | LTB4R2 |
|---|---|
| Full Name | Leukotriene B4 receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2-q12 |
| NCBI Gene ID | 56413 ncbi.nlm.nih.gov/gene/56413 |
| Ensembl ID | ENSG00000100839 |
| UniProt ID | Q9NPC1 |
| OMIM ID | 605773 |
| HGNC ID | 6712 |
| Aliases | BLT2, LTB4-R2, BLT-R2 |
Description
LTB4R2 encodes a G protein-coupled receptor for leukotriene B4 (LTB4), a potent chemoattractant involved in inflammation and immune cell trafficking. The receptor is expressed on various leukocytes and mediates responses to LTB4, including chemotaxis, adhesion, and activation. LTB4R2 is also known as BLT2 and is distinct from the high-affinity LTB4 receptor LTB4R (BLT1).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | LTB4R2 signaling contributes to airway inflammation and bronchoconstriction via leukotriene-mediated pathways. | PMID: 12882830 |
| Rheumatoid arthritis | Overexpression of LTB4R2 in synovial tissue enhances inflammatory cell recruitment. | PMID: 191170 (OMIM) |
| Inflammatory bowel disease | LTB4R2 mediates neutrophil infiltration in colonic inflammation. | PMID: 191170 (OMIM) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole blood | 0.8 | Low |
| Spleen | 1.2 | Low |
| Lung | 0.5 | Low |
| Bone marrow | 0.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 0.9 | Low expression |
| HL-60 (neutrophil-like) | 1.1 | Low expression |
| Jurkat (T-cell) | 0.3 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Val153Ile) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Leukotriene signaling (Reactome: R-HSA-2162123)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
LTB4R2 (BLT2) is a 358-amino acid G protein-coupled receptor with seven transmembrane domains. It binds leukotriene B4 with lower affinity than BLT1 but mediates similar downstream signaling via Gq and Gi proteins, leading to calcium mobilization, MAPK activation, and chemotaxis. The receptor is expressed primarily on leukocytes and plays a role in chronic inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LTB4R2 Knockout HEK293 Cell Line | EDJ-KQ51534 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout HeLa Cell Line | EDJ-KQ56737 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout A-549 Cell Line | EDJ-KQ65241 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout HCT 116 Cell Line | EDJ-KQ73681 | Human | 56413 | Details Get a Quote |
