LTB4R (Leukotriene B4 Receptor)
A G protein-coupled receptor for leukotriene B4, involved in inflammation and immune response.
Gene Information Card
| Symbol | LTB4R |
|---|---|
| Full Name | Leukotriene B4 Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 14q12 |
| NCBI Gene ID | 1241 ncbi.nlm.nih.gov/gene/1241 |
| Ensembl ID | ENSG00000100888 |
| UniProt ID | Q15722 |
| OMIM ID | 601531 |
| HGNC ID | 6713 |
| Aliases | BLT1, BLTR, CMKRL1, GPR16, LTB4R1, P2RY7 |
Description
LTB4R encodes a G protein-coupled receptor (GPCR) that binds leukotriene B4 (LTB4), a potent chemoattractant and pro-inflammatory mediator. The receptor is primarily expressed on leukocytes and mediates chemotaxis, adhesion, and activation of inflammatory cells. It plays a key role in asthma, allergic inflammation, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | LTB4R activation promotes eosinophil and neutrophil recruitment to airways, contributing to airway hyperresponsiveness and inflammation. | ClinVar, OMIM |
| Inflammatory bowel disease | LTB4R signaling enhances leukocyte infiltration into intestinal mucosa, exacerbating colitis. | NCBI Gene, PubMed |
| Cancer (e.g., colorectal, pancreatic) | LTB4R overexpression or gain-of-function mutations may promote tumor cell proliferation, migration, and metastasis via PI3K/Akt and MAPK pathways. | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Lung | 8.9 | Low |
| Whole blood | 15.3 | High |
| Small intestine | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocytic leukemia) | 18.7 | High expression |
| HL-60 (promyelocytic leukemia) | 14.2 | High expression |
| A549 (lung carcinoma) | 2.3 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% | Unknown functional effect; reported in COSMIC |
| c.457C>T (p.Pro153Ser) | Missense | <0.1% | May alter ligand binding; ClinVar uncertain significance |
| c.1-?_*? (whole gene deletion) | Deletion | Rare | Loss of function; associated with altered immune response |
Mutation functional classification
Loss of Function (LOF)
Rare deletions or nonsense mutations reduce receptor expression or signaling, impairing LTB4-mediated chemotaxis.
Gain of Function (GOF)
Missense mutations (e.g., p.Arg67His) may increase receptor activity, enhancing inflammatory responses.
Dominant Negative (DN)
No dominant-negative mutations reported for LTB4R.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Leukotriene B4 signaling (Reactome: R-HSA-2162123)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Chemokine signaling pathway (KEGG: hsa04062)
Protein Summary
LTB4R (BLT1) is a 352-amino acid GPCR with seven transmembrane domains. It is activated by LTB4, leading to intracellular calcium mobilization, activation of PI3K, MAPK, and NF-κB pathways. The receptor is critical for neutrophil and eosinophil chemotaxis and is a therapeutic target for inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LTB4R Knockout HEK293 Cell Line | EDJ-KQ4301 | Human | 1241 | Details Get a Quote |
| LTB4R Knockout A-549 Cell Line | EDJ-KQ26789 | Human | 1241 | Details Get a Quote |
| LTB4R Knockout HCT 116 Cell Line | EDJ-KQ26790 | Human | 1241 | Details Get a Quote |
| LTB4R Knockout HeLa Cell Line | EDJ-KQ26791 | Human | 1241 | Details Get a Quote |
| LTB4R2 Knockout HEK293 Cell Line | EDJ-KQ51534 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout HeLa Cell Line | EDJ-KQ56737 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout A-549 Cell Line | EDJ-KQ65241 | Human | 56413 | Details Get a Quote |
| LTB4R2 Knockout HCT 116 Cell Line | EDJ-KQ73681 | Human | 56413 | Details Get a Quote |
