LTA (Lymphotoxin Alpha) Gene
TNF Superfamily Member, Immune Regulator, and Disease Association
Gene Information Card
| Symbol | LTA |
|---|---|
| Full Name | Lymphotoxin Alpha |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.33 |
| NCBI Gene ID | 4049 ncbi.nlm.nih.gov/gene/4049 |
| Ensembl ID | ENSG00000204490 |
| UniProt ID | P01374 |
| OMIM ID | 153440 |
| HGNC ID | 6709 |
| Aliases | LT, TNFB, TNFSF1 |
Description
LTA (lymphotoxin alpha) is a member of the tumor necrosis factor (TNF) superfamily. It encodes a cytokine produced by lymphocytes that mediates inflammatory and immune responses. LTA forms heterotrimers with lymphotoxin beta (LTB) to activate NF-kappaB pathways, playing roles in lymphoid organ development, apoptosis, and host defense. Genetic variants in LTA are associated with susceptibility to myocardial infarction, asthma, and autoimmune diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Myocardial Infarction | LTA polymorphisms (e.g., rs909253) alter cytokine expression, promoting vascular inflammation and atherosclerosis | NCBI Gene, OMIM |
| Asthma | LTA variants influence airway inflammation and immune hyperresponsiveness | NCBI Gene, OMIM |
| Rheumatoid Arthritis | LTA contributes to synovial inflammation via TNF pathway activation | NCBI Gene, OMIM |
| Systemic Lupus Erythematosus | LTA dysregulation linked to autoantibody production and immune complex deposition | NCBI Gene, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.3 nTPM | Medium |
| Spleen | 10.1 nTPM | Medium |
| Bone marrow | 8.5 nTPM | Low |
| Lung | 4.2 nTPM | Low |
| Whole blood | 3.8 nTPM | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.2 nTPM | High expression |
| Raji (Burkitt lymphoma) | 12.8 nTPM | High expression |
| K-562 (chronic myelogenous leukemia) | 6.1 nTPM | Low expression |
| HeLa (cervical carcinoma) | 2.5 nTPM | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs909253 (A>G) | SNP | 0.35 (global) | Alters LTA expression; associated with myocardial infarction and asthma |
| rs1041981 (C>A) | SNP | 0.28 (global) | Missense variant (Thr26Asn); linked to autoimmune disease risk |
| c.1A>G | SNP | <0.01 | Start codon loss; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare start codon mutations (e.g., c.1A>G) predicted to abolish protein expression.
Gain of Function (GOF)
Not well documented; some SNPs (e.g., rs909253) may increase LTA transcription.
Dominant Negative (DN)
Not reported for LTA.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TNF signaling pathway (KEGG hsa04668)
• NF-kappa B signaling pathway (KEGG hsa04064)
• Cytokine-cytokine receptor interaction (KEGG hsa04060)
Protein Summary
Lymphotoxin alpha (LTA) is a 25 kDa secreted cytokine of the TNF superfamily. It is primarily produced by activated T and B lymphocytes. LTA can form soluble homotrimers or membrane-bound heterotrimers with LTB. The LTA-LTB complex binds to LTBR (lymphotoxin beta receptor) to activate NF-kappaB and MAPK pathways, regulating lymphoid organogenesis, inflammation, and cell survival. LTA is implicated in atherosclerosis, asthma, and autoimmune diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LTA Knockout HEK293 Cell Line | EDJ-KQ571 | Human | 4049 | Details Get a Quote |
| CLTA Knockout HEK293 Cell Line | EDJ-KQ2164 | Human | 1211 | Details Get a Quote |
| LTAP1 Knockout HEK293 Cell Line | EDJ-KQ3873 | Human | 25912 | Details Get a Quote |
| LTA4H Knockout HEK293 Cell Line | EDJ-KQ5147 | Human | 4048 | Details Get a Quote |
| LTAP1 Knockout A-549 Cell Line | EDJ-KQ26078 | Human | 25912 | Details Get a Quote |
| LTAP1 Knockout HCT 116 Cell Line | EDJ-KQ26079 | Human | 25912 | Details Get a Quote |
| LTA4H Knockout A-549 Cell Line | EDJ-KQ28116 | Human | 4048 | Details Get a Quote |
| LTA4H Knockout HCT 116 Cell Line | EDJ-KQ28117 | Human | 4048 | Details Get a Quote |
| LTA4H Knockout HeLa Cell Line | EDJ-KQ28118 | Human | 4048 | Details Get a Quote |
| CLTA Knockout A-549 Cell Line | EDJ-KQ22367 | Human | 1211 | Details Get a Quote |
| CLTA Knockout HCT 116 Cell Line | EDJ-KQ22368 | Human | 1211 | Details Get a Quote |
| CLTA Knockout HeLa Cell Line | EDJ-KQ22369 | Human | 1211 | Details Get a Quote |
| LTAP1 Knockout HeLa Cell Line | EDJ-KQ24727 | Human | 25912 | Details Get a Quote |
| LTA Knockout HeLa Cell Line | EDJ-KQ53808 | Human | 4049 | Details Get a Quote |
| LTA Knockout A-549 Cell Line | EDJ-KQ62289 | Human | 4049 | Details Get a Quote |
Displaying Records 1 To 15 Of 16 Records
