LSM1 Homolog, U6 Small Nuclear RNA and mRNA Degradation Associated
A core component of the LSM1-7 complex involved in mRNA decapping and decay
Gene Information Card
| Symbol | LSM1 |
|---|---|
| Full Name | LSM1 Homolog, U6 Small Nuclear RNA and mRNA Degradation Associated |
| Gene Type | Protein coding |
| Chromosomal Location | 8p11.23 |
| NCBI Gene ID | 27257 ncbi.nlm.nih.gov/gene/27257 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | O15116 |
| OMIM ID | 607281 |
| HGNC ID | 20458 |
| Aliases | YJL124C, CASM, LSM1P, Sm-like protein 1 |
Description
LSM1 encodes a member of the LSM (Like Sm) family of RNA-binding proteins. The protein is a component of the LSM1-7 complex, which localizes to cytoplasmic processing bodies (P-bodies) and is essential for the decapping and degradation of mRNA. It also participates in the splicing and stability of U6 small nuclear RNA. LSM1 is involved in post-transcriptional gene regulation and has been implicated in cellular proliferation and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | LSM1 overexpression correlates with poor prognosis; may promote cell proliferation and migration | PMID: 25605274 |
| Hepatocellular carcinoma | Upregulation of LSM1 associated with tumor progression and metastasis | PMID: 29351289 |
| Lung cancer | LSM1 knockdown reduces cell viability and induces apoptosis in lung cancer cell lines | PMID: 27633000 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 10.5 | Medium |
| Brain | 6.3 | Low |
| Liver | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical carcinoma; high expression |
| A549 | 14.7 | Lung carcinoma; moderate expression |
| MCF7 | 12.1 | Breast carcinoma; moderate expression |
| HEK293 | 9.8 | Embryonic kidney; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential start loss |
| c.214C>T | Missense | <0.01% | p.Arg72Cys; uncertain significance |
| c.337G>A | Synonymous | <0.01% | p.Gly113Gly; no functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • mRNA catabolic process | • RNA splicing |
| • U6 snRNA binding | • cytoplasmic processing body |
| • mRNA decapping complex |
Pathways
• mRNA surveillance pathway (KEGG: hsa03015)
• RNA degradation (KEGG: hsa03018)
Protein Summary
LSM1 is a 133-amino-acid protein (15.5 kDa) that contains an Sm domain typical of RNA-binding proteins. It forms a heteroheptameric complex with LSM2-7, which binds to the 3' end of U6 snRNA and to the 5' cap of mRNA to facilitate decapping. The protein is predominantly cytoplasmic and localizes to P-bodies. Its structure includes a conserved RNA-binding motif that recognizes oligo(A) tails.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LSM14A Knockout HEK293 Cell Line | EDJ-KQ8382 | Human | 26065 | Details Get a Quote |
| LSM1 Knockout HEK293 Cell Line | EDJ-KQ8734 | Human | 27257 | Details Get a Quote |
| LSM10 Knockout HEK293 Cell Line | EDJ-KQ9528 | Human | 84967 | Details Get a Quote |
| LSM14B Knockout HEK293 Cell Line | EDJ-KQ11241 | Human | 149986 | Details Get a Quote |
| LSM14A Knockout HeLa Cell Line | EDJ-KQ33100 | Human | 26065 | Details Get a Quote |
| LSM1 Knockout HCT 116 Cell Line | EDJ-KQ34976 | Human | 27257 | Details Get a Quote |
| LSM1 Knockout HeLa Cell Line | EDJ-KQ34977 | Human | 27257 | Details Get a Quote |
| LSM1 Knockout A-549 Cell Line | EDJ-KQ33711 | Human | 27257 | Details Get a Quote |
| LSM14A Knockout A-549 Cell Line | EDJ-KQ34434 | Human | 26065 | Details Get a Quote |
| LSM14A Knockout HCT 116 Cell Line | EDJ-KQ34435 | Human | 26065 | Details Get a Quote |
| LSM10 Knockout A-549 Cell Line | EDJ-KQ37550 | Human | 84967 | Details Get a Quote |
| LSM10 Knockout HCT 116 Cell Line | EDJ-KQ37551 | Human | 84967 | Details Get a Quote |
| LSM10 Knockout HeLa Cell Line | EDJ-KQ37552 | Human | 84967 | Details Get a Quote |
| LSM14B Knockout A-549 Cell Line | EDJ-KQ39329 | Human | 149986 | Details Get a Quote |
| LSM14B Knockout HCT 116 Cell Line | EDJ-KQ39330 | Human | 149986 | Details Get a Quote |
