LRRC75B (Leucine Rich Repeat Containing 75B)
A poorly characterized gene encoding a leucine-rich repeat protein, with limited functional annotation and no established disease association.
Gene Information Card
| Symbol | LRRC75B |
|---|---|
| Full Name | Leucine Rich Repeat Containing 75B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q24.33 |
| NCBI Gene ID | 388796 ncbi.nlm.nih.gov/gene/388796 |
| Ensembl ID | ENSG00000119915 |
| UniProt ID | Q6ZTR5 |
| OMIM ID | Not available |
| HGNC ID | 33735 |
| Aliases | C10orf91 |
Description
LRRC75B (Leucine Rich Repeat Containing 75B) is a protein-coding gene located on chromosome 10q24.33. It encodes a protein containing leucine-rich repeats (LRRs), which are typically involved in protein-protein interactions. The gene is also known by the alias C10orf91. Currently, the function of LRRC75B is not well characterized, and no specific disease associations have been established. Expression data indicate low to moderate levels in various tissues, with highest expression in the thyroid and adrenal gland.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No established disease association | Not applicable | No curated disease links in OMIM, ClinVar, or COSMIC as of current knowledge. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 8.7 | Low |
| Adrenal gland | 7.9 | Low |
| Testis | 6.5 | Low |
| Kidney | 5.2 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 5.0 | Cervical adenocarcinoma; low expression |
| A549 | 4.5 | Lung carcinoma; low expression |
| MCF7 | 3.8 | Breast adenocarcinoma; low expression |
| HEK293 | 6.0 | Embryonic kidney; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No pathogenic or likely pathogenic variants reported in ClinVar or COSMIC. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations or their effects.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (inferred from sequence model) | • leucine-rich repeat domain (inferred from sequence model) |
Protein Summary
The LRRC75B protein (UniProt Q6ZTR5) is predicted to contain leucine-rich repeats, which are structural motifs involved in protein-protein interactions. The protein is likely localized to the cytoplasm or membrane, but experimental validation is lacking. Its function remains unknown, and no post-translational modifications or interaction partners have been experimentally confirmed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC75B Knockout HEK293 Cell Line | EDJ-KQ14144 | Human | 388886 | Details Get a Quote |
| LRRC75B Knockout A-549 Cell Line | EDJ-KQ44072 | Human | 388886 | Details Get a Quote |
| LRRC75B Knockout HCT 116 Cell Line | EDJ-KQ44073 | Human | 388886 | Details Get a Quote |
| LRRC75B Knockout HeLa Cell Line | EDJ-KQ44074 | Human | 388886 | Details Get a Quote |
