LRRC75A
Leucine Rich Repeat Containing 75A
Gene Information Card
| Symbol | LRRC75A |
|---|---|
| Full Name | Leucine Rich Repeat Containing 75A |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 388407 ncbi.nlm.nih.gov/gene/388407 |
| Ensembl ID | ENSG00000187601 |
| UniProt ID | Q8N6T3 |
| OMIM ID | - |
| HGNC ID | HGNC:28668 |
| Aliases | MGC16384, FLJ32786 |
Description
LRRC75A (Leucine Rich Repeat Containing 75A) is a protein-coding gene located on chromosome 17q25.3. The encoded protein contains leucine-rich repeats, which are typically involved in protein-protein interactions. The specific biological function of LRRC75A is not fully characterized, but it is predicted to play a role in cellular signaling or structural processes. Expression data suggest broad tissue distribution with low to moderate levels.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | - | - |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Brain | 1.8 | Low |
| Lung | 1.5 | Low |
| Liver | 1.0 | Low |
| Kidney | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.5 | Low expression |
| HeLa | 1.9 | Low expression |
| K562 | 1.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | - | - | - |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
The LRRC75A protein (UniProt Q8N6T3) is a 316-amino acid protein containing leucine-rich repeats. Its exact molecular function and cellular localization remain largely unknown, but it is predicted to be involved in protein-protein interactions. No significant functional studies have been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC75A Knockout HEK293 Cell Line | EDJ-KQ14142 | Human | 388341 | Details Get a Quote |
| LRRC75A Knockout HCT 116 Cell Line | EDJ-KQ44071 | Human | 388341 | Details Get a Quote |
| LRRC75A Knockout HeLa Cell Line | EDJ-KQ42844 | Human | 388341 | Details Get a Quote |
| LRRC75A Knockout A-549 Cell Line | EDJ-KQ68479 | Human | 388341 | Details Get a Quote |
