LRRC74B
Leucine Rich Repeat Containing 74B
Gene Information Card
| Symbol | LRRC74B |
|---|---|
| Full Name | Leucine Rich Repeat Containing 74B |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000205755 |
| UniProt ID | A6NKD9 |
| OMIM ID | - |
| HGNC ID | 37284 |
| Aliases | MGC16384, FLJ46361 |
Description
LRRC74B (Leucine Rich Repeat Containing 74B) is a protein-coding gene located on chromosome 22q13.1. The encoded protein contains leucine-rich repeats, which are often involved in protein-protein interactions. Currently, limited functional characterization is available, and no specific disease associations have been established in major databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | - | - |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.5 | Low |
| Brain | 0.2 | Low |
| Lung | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.3 | Low expression |
| K562 | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations in COSMIC or ClinVar | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The LRRC74B protein is predicted to contain leucine-rich repeats, suggesting a role in protein-protein interactions. No experimental functional data are currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC74B Knockout HEK293 Cell Line | EDJ-KQ11598 | Human | 400891 | Details Get a Quote |
| LRRC74B Knockout HeLa Cell Line | EDJ-KQ60280 | Human | 400891 | Details Get a Quote |
| LRRC74B Knockout A-549 Cell Line | EDJ-KQ68742 | Human | 400891 | Details Get a Quote |
| LRRC74B Knockout HCT 116 Cell Line | EDJ-KQ77109 | Human | 400891 | Details Get a Quote |
