LRRC74A Gene: Function, Expression, and Disease Associations | Biomedical Database Summary

LRRC74A (leucine rich repeat containing 74A) is a protein-coding gene located on chromosome 14q24.3. It encodes a protein containing leucine-rich repeats (LRRs), which are motifs often involved in protein-protein interactions. The gene is expressed in various tissues, with notable levels in the testis and certain brain regions. Its function is not fully characterized, but based on expression and homology, it may play a role in ciliary assembly or function. Altered expression has been observed in some cancers, suggesting potential involvement in tumorigenesis.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways curated in major databases; may be involved in ciliary transport or assembly based on LRR domain.

The LRRC74A protein is 512 amino acids long and contains leucine-rich repeats (LRRs) that are predicted to mediate protein-protein interactions. It is localized predominantly in the cytoplasm, with potential association with ciliary structures. The protein's exact function is unknown, but its expression pattern and domain architecture suggest a role in ciliary biology or intracellular signaling. Structural predictions indicate a solenoid-like LRR domain typical of proteins involved in immune responses or neuronal development, but further studies are needed.