LRRC72
Leucine Rich Repeat Containing 72
Gene Information Card
| Symbol | LRRC72 |
|---|---|
| Full Name | Leucine Rich Repeat Containing 72 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q36.1 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000205643 |
| UniProt ID | A6NKD9 |
| OMIM ID | Not available |
| HGNC ID | 37230 |
| Aliases | FLJ45831 |
Description
LRRC72 (Leucine Rich Repeat Containing 72) is a protein-coding gene located on chromosome 7q36.1. The encoded protein contains leucine-rich repeats, which are typically involved in protein-protein interactions. The specific biological function of LRRC72 is not fully characterized, but it is predicted to play a role in cellular signaling or adhesion processes. Expression data suggest low to moderate levels in certain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Brain | 1.5 | Low |
| Lung | 1.0 | Low |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.2 | Low expression |
| HeLa | 0.9 | Low expression |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | Not available |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The LRRC72 protein (UniProt A6NKD9) is predicted to contain leucine-rich repeats, suggesting involvement in protein-protein interactions. Its molecular function and cellular role remain largely uncharacterized, with no confirmed enzymatic or signaling activity reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC72 Knockout HEK293 Cell Line | EDJ-KQ14141 | Human | 100506049 | Details Get a Quote |
| LRRC72 Knockout HeLa Cell Line | EDJ-KQ60908 | Human | 100506049 | Details Get a Quote |
| LRRC72 Knockout A-549 Cell Line | EDJ-KQ69383 | Human | 100506049 | Details Get a Quote |
| LRRC72 Knockout HCT 116 Cell Line | EDJ-KQ77736 | Human | 100506049 | Details Get a Quote |
